Publications by authors named "Wagner G Horta"
Pattern of abnormalities on gray matter in patients with medial temporal lobe epilepsy and hippocampal sclerosis: An updated meta-analysis.
Clin Neurol Neurosurg
October 2024
Article Synopsis
- * This study examined gray matter changes in patients with mesial temporal lobe epilepsy (MTLE) with HS, using advanced imaging techniques and comparing results with healthy control groups.
- * Significant gray matter loss was found in both hemispheres, with specific brain regions affected, which may provide future insights for diagnostics, treatments, and understanding the progression of MTLE.
Background: Recent studies have reported that peripheral neuropathy (PN) is common in patients with Parkinson's disease (PD) and raised the possibility that levodopa neurotoxicity is the main culprit.
Methods: We evaluated the presence of large & small (autonomic) fiber PN in 54 consecutive patients with PD or parkinsonism in a tertiary outpatient clinic from Brazil. Initial PN screening consisted of history/neurological exam and skin wrinkling test (SWT).
Genetic association study of the HLA class II alleles DRB1, DQA1, and DQB1 in patients with pharmacoresistant temporal lobe epilepsy associated with mesial hippocampal sclerosis.
Seizure
September 2015
Article Synopsis
- Temporal lobe epilepsy (TLE) is common in adults and its connection with neuroinflammation, particularly in cases like TLE with mesial hippocampal sclerosis (TLE-HS), is being explored for genetic susceptibility.
- The study involved analyzing blood samples from 42 individuals with drug-resistant TLE-HS and 89 healthy controls to investigate the association of TLE-HS with specific HLA class II alleles using advanced genetic testing methods.
- While the HLA-DRB1*13:02 allele showed a statistically significant difference in frequency between the patient and control groups, this significance diminished after adjusting for multiple comparisons, indicating it may have a weak association with TLE-HS susceptibility.
We conducted a 320 year retrospective survey of the history and genealogy of a large Brazilian family with SCA7. The ancestral couple was from the State of Ceará, Brazil, and the genealogical tree was composed of 577 individuals, including 217 males (37.6%), 255 females (44.
View Article and Find Full Text PDFObjective: To evaluate the presence of structural disorders of the corpora cavernosa in patients with erectile dysfunction (ED), as despite new drugs being effective in many men with ED, some aspects of structural disorders of the corpora cavernosa remain unknown.
Materials And Methods: Biopsy specimens were taken from the corpora cavernosa of seven patients (mean age 57.8 years, range 51-72) with severe ED who had a penile prosthesis implanted.