Publications by authors named "Wagner Eduardo da Silva"
Bioconjugate based on cisplatin and bacterial exopolysaccharide with reduced side effects: A novel proposal for cancer treatment.
Gian Carlo D Angelo de Queiroz Fernanda Carolina Ribeiro Dias Sandra Maria de Torres Márcia de Figueiredo Pereira Danielle Barbosa Morais Wagner Eduardo da Silva Valdemiro Amaro de Silva Junior
J Trace Elem Med Biol
May 2024
Background: In the search for alternatives that attenuate the toxicity associated to oncologic treatment with cisplatin (CDDP) and considering the potential health-beneficial properties of exopolysaccharides (EPS) produced by lactic acid bacteria, it was aimed on this study to evaluate the cytotoxic, toxicologic and antitumoral efficacy of a bioconjugate based on CDDP and EPS, on the experimental tumor of sarcoma 180.
Methods: After the synthesis of the cis-[Pt(NH3)2(Cl)2] complex and of the conjugate containing Lactobacillus fermentum exopolysaccharide was tested both in vitro and in vivo for evaluating the acute toxicity.
Results: The antitumoral study was performed using mice transplanted with sarcoma 180.