The utility of limited Spanish proficiency in interpreted genetic counseling sessions.

Professional interpreters are an integral component of healthcare for Spanish-speaking individuals with limited English proficiency (LEP). Research has demonstrated that errors in interpretation are common and can contribute to poor outcomes for Spanish-speaking clients. Providers with some Spanish proficiency may be able to detect clinically significant interpretation errors, potentially limiting negative clinical outcomes and helping to reduce health disparities for clients with LEP.

Family Perspectives on Newborn Screening for X-Linked Adrenoleukodystrophy in California.

X-linked adrenoleukodystrophy (ALD) is caused by gene variants in the gene, resulting in a varied clinical spectrum. Males with ALD present with symptoms ranging from isolated adrenal insufficiency and slowly progressive myelopathy to severe cerebral demyelination. Females who are heterozygous for ALD typically develop milder symptoms by late adulthood.

C/EBPβ regulates the M2 transcriptome in β-adrenergic-stimulated macrophages.

At the M2 terminal of the macrophage activation spectrum, expression of genes is regulated by transcription factors that include STAT6, CREB, and C/EBPβ. Signaling through β-adrenergic receptors drives M2 activation of macrophages, but little is known about the transcription factors involved. In the present study, we found that C/EBPβ regulates the signaling pathway between β-adrenergic stimulation and expression of Arg1 and several other specific genes in the greater M2 transcriptome.

Demonstration of tuning to stimulus orientation in the human visual cortex: a high-resolution fMRI study with a novel continuous and periodic stimulation paradigm.

Cells in the animal early visual cortex are sensitive to contour orientations and form repeated structures known as orientation columns. At the behavioral level, there exist 2 well-known global biases in orientation perception (oblique effect and radial bias) in both animals and humans. However, their neural bases are still under debate.

Processing of infant-directed speech by adults.

Adults typically address infants in a special speech mode called infant-directed speech (IDS). IDS is characterized by a special prosody (i.e.

Correction of 3D rigid body motion in fMRI time series by independent estimation of rotational and translational effects in k-space.

In functional magnetic resonance imaging (fMRI), even subvoxel motion dramatically corrupts the blood oxygenation level-dependent (BOLD) signal, invalidating the assumption that intensity variation in time is primarily due to neuronal activity. Thus, correction of the subject's head movements is a fundamental step to be performed prior to data analysis. Most motion correction techniques register a series of volumes assuming that rigid body motion, characterized by rotational and translational parameters, occurs.

A temporal frequency-dependent functional architecture in human V1 revealed by high-resolution fMRI.

Although cortical neurons with similar functional properties often cluster together in a columnar organization, only ocular dominance columns, the columnar structure representing segregated anatomical input (from one of the two eyes), have been found in human primary visual cortex (V1). It has yet to be shown whether other columnar organizations that arise only from differential responses to stimulus properties also exist in human V1. Using high-resolution functional magnetic resonance imaging, we have found such a functional architecture containing domains that respond preferentially to either low or high temporal frequency.

Contrast adaptation and representation in human early visual cortex.

The human visual system can distinguish variations in image contrast over a much larger range than measurements of the static relationship between contrast and response in visual cortex would suggest. This discrepancy may be explained if adaptation serves to re-center contrast response functions around the ambient contrast, yet experiments on humans have yet to report such an effect. By using event-related fMRI and a data-driven analysis approach, we found that contrast response functions in V1, V2, and V3 shift to approximately center on the adapting contrast.

Consistent and precise localization of brain activity in human primary visual cortex by MEG and fMRI.

The tomographic localization of activity within human primary visual cortex (striate cortex or V1) was examined using whole-head magnetoencephalography (MEG) and 4-T functional magnetic resonance imaging (fMRI) in four subjects. Circular checkerboard pattern stimuli with radii from 1.8 to 5.

Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging.

We mapped ocular dominance columns (ODCs) in normal human subjects using high-field (4 T) functional magnetic resonance imaging (fMRI) with a segmented echo planar imaging technique and an in-plane resolution of 0.47 x 0.47 mm(2).

Cerebral polyopia with extrastriate quadrantanopia: report of a case with magnetic resonance documentation of V2/V3 cortical infarction.

This is a case report of the occurrence of cerebral diplopia with right-side superior homonymous quadrantanopia in a young woman after chiropractic neck manipulation. Magnetic resonance imaging confirmed an infarct in the left inferior V2/V3 (extrastriate) cortex. The characteristics of the diplopia are illustrated with the patient's drawings, and persisting abnormalities in perception are described in the area of the initial field defect after static (computed) visual field testing yielded normal results.

Imaging lungs using inert fluorinated gases.

Rat lungs were imaged by 19F projection MRI of hexafluoroethane, mixed with 20% oxygen to form the inhaled gas. The 3D image had 700 microm resolution, and the data took 4.3 h to acquire.

Harmonic interactions in health care facilities, Part II: Practical handling of harmonic interactions.

This is part two in a two-part series aimed at helping the reader understand and prepare for a world of electrical peculiarities. Part one offered an introduction to harmonics. This document covers practical issues involving the handling and mitigation of harmonic distortion.

Harmonic interactions in health care facilities.

This document is the beginning of a two-part series that will help the reader understand and prepare for a world of electrical peculiarities. Part I offers an introduction to the problematic world of harmonics and their effects on medical equipment. Part II will take the subject a step further to cover the practical issues involving the handling and mitigation of harmonic distortion.

Velocity distribution of slow fluid flows in Bentheimer sandstone: an NMRI and propagator study.

This work addresses the special problems of measuring flow velocity distributions in rock by NMR methods. Specifically, these problems are to measure very slow flows as well as flows in the presence of background magnetic field gradients caused by heterogeneities of the rock. We modify a stimulated echo sequence for use in diffusion measurements, in order to maximize velocity sensitivity and minimize background gradient effects.

Stabilization of spinal injury for early transfer.

We have reviewed the means of transport and type of stabilization used for all patients with acute spinal cord injuries (SCI) transferred to our center since 1985 to determine what effect these variables may have had on change in level of impairment and probability of neurologic improvement after arrival. Sixty-one patients were reviewed, 47 males and 14 females, with a mean age of 34 years. Twenty-five patients (41%) were transported by ground ambulance, 33 (54%) by helicopter, three (5%) by fixed-wing aircraft.

Acquired resistance to rifampicin by Mycobacterium kansasii.

Two patients with Mycobacterium kansasii infection of the lung had organisms sensitive to rifampicin. Following treatment, essentially with rifampicin alone, the patients began to excrete organisms completely resistant to rifampicin. The ability of M.

Isolation of mycobacteria from clinical specimens by use of selective 7H11 medium.

7H11 agar containing carbenicillin, amphotericin B, polymyxin B and trimethoprim lactate (selective 7H11 or S7H11) was used for the selective isolation of mycobacteria from clinical specimens. This medium as previously described contained 100 mug. carbenicillin per ml.