Parkinsonism-like Disease Induced by Rotenone in Rats: Treatment Role of Curcumin, Dopamine Agonist and Adenosine A Receptor Antagonist.

Background: Parkinsonism is a neurodegenerative disorder that affects elderly people worldwide.

Methods: Curcumin, adenosine AR antagonist (ZM241385) and Sinemet (L-dopa) were evaluated against Parkinson's disease (PD) induced by rotenone in rats, and the findings were compared to our previous study on mice model.

Results: Rats injected with rotenone showed severe alterations in adenosine A receptor gene expression, oxidative stress markers, inflammatory mediator, energetic indices, apoptotic marker and DNA fragmentation levels as compared to the control group.

Impact of Silver Nanoparticles on Gene Expression in Producer Aflatoxin B1.

Aim: In this study, we evaluated the effect of silver nanoparticles (AgNPs) on the production of aflatoxin B (AFB) through assessment the transcription activity of aflatoxin biosynthesis pathway genes in ATCC28542.

Material And Methods: The mRNAs were quantitative by Real Time-polymerase chain reaction (qRT-PCR) of grown in yeast extract sucrose (YES) medium containing AgNPs. Specific primers that are involved in the AFB biosynthesis which highly specific to , O-methyltransferase gene (), were designed and used to detect the fungus activity by quantitative PCR assay.