Oxidant-antioxidant status in Egyptian children with sickle cell anemia: a single center based study.

Objective: the present study was conducted to investigate the oxidant-antioxidant status in Egyptian children with sickle cell anemia.

Methods: the serum levels of total antioxidant capacity (TAO), paraoxonase (PON), vitamin E, nitrite, and malondialdehyde (MDA) were measured in 40 steady state children with homozygous sickle cell anemia (24 males and 16 females) and 20 apparently healthy age- and gender-matched controls.

Results: mean serum TAO, PON, vitamin E, and nitrite levels were significantly lower in the group with sickle cell anemia, whereas mean serum MDA was significantly higher in these children compared to controls.