Publications by authors named "Wafa AlGhamdi"

Article Synopsis
  • The CRISPR-Cas9 system is a groundbreaking gene editing tool being researched for treating thalassemia and sickle cell disease (SCD).
  • A study reviewed clinical trials from multiple databases, identifying 6 eligible studies involving 115 patients, which used CRISPR/Cas9 to target specific gene enhancers and promoters.
  • Results showed that patients experienced increased fetal hemoglobin, improved hemoglobin levels, transfusion independence in thalassemia, and reduced pain episodes in SCD, indicating the potential of CRISPR/Cas9 as a one-time functional cure for these blood disorders.
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Aim: This study assessed the correlation between corneal biomechanical properties measured with Corvis ST (CST) and retinal nerve fiber layer thickness profile, anterior lamina cribrosa surface depth, and other optic nerve head parameters in healthy Saudi females.

Methods: This study included 62 eyes (only right eyes) of 62 healthy Saudi females aged from 20 to 39 yrs. A complete ophthalmologic assessment was performed for all participants.

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Primary cutaneous diffuse large B-cell lymphomas (PCDLBCLs) represent approximately 10%-20% of primary cutaneous B-cell lymphomas. They present as nodules in the skin or as rapidly growing aggressive behavior tumors with a poor prognosis. In this article, we report a case of PCDLBCL presented with an aggressively enlarging skin lesion on the right cheek.

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Objective: To assess the performance of the new EULAR/ACR criteria, particularly for early detection of cSLE, in comparison to the SLICC criteria among the pediatric population in multiple centers in Saudi Arabia.

Methods: We conducted a retrospective study that enrolled pediatric patients up to the age of 14 years who've been diagnosed with SLE and followed in pediatric rheumatology clinics at 9 multi-tertiary hospitals in Saudi Arabia from 2010 to 2021 as a case group and were compared to a similar group of pediatric patients who've had defined rheumatological diseases other than SLE with a positive ANA titer (≥1:80) as controls. In total, 245 patients were included and distributed as 129 cases (diagnosed by expert pediatric rheumatologists) versus 116 patients in the control group.

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Background: The diagnostic criteria for hypertension have recently been redefined by the American College of Cardiology/ American Heart Association (ACC/AHA). Data on the new prevalence of hypertension in different countries are emerging, but none, to date, from Saudi Arabia.

Aims: This study aimed to determine the impact of the 2017 ACC/AHA hypertension guideline on the prevalence and determinants of hypertension in young Saudi women.

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This study aimed to determine the prevalence of hypertension and high normal blood pressure and their risk factors among young adult Saudi females. A prospective cross-sectional study was conducted in a women's university. A questionnaire evaluated the subjects' demographic data and risk factors for hypertension and the blood pressure, height, and weight were recorded.

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