Irisin expression and (rs3480) gene polymorphism in type 2 diabetic patients with and without CAD.

Background: Irisin was found to correlate with coronary artery disease (CAD) in diabetic patients. This study investigated the association of irisin and (SNP rs3480) with the presence and severity of CAD in T2DM.

Methods: This cross-sectional study included 100 patients with T2DM divided into two groups, DM group ( = 50), including patients without CAD and CAD group ( = 50), including those confirmed to have CAD by coronary angiography.

Age-Dependent Differential Expression of Apoptotic Markers in Rat Oral Mucosa.

Objective: This study tests the hypothesis that gingival tissue produces age-dependent activation of apoptotic markers. Methods: To address the hypothesis, a prospective experimental study was conducted on 20 adult male albino rats, which were divided into two groups. Group 1 comprised rats aged six months (weighing 150–200 g), and group 2 included old rats aged one year (weighing 250–300 g).

Acute liver failure: an uncommon complication of commonly used medication.

The incidence of drug-related acute liver failure is approximately 14 per 100,000 populations. Drug-induced liver injury may take place through a variety of mechanism. Withdrawal of the offending agent may result in complete recovery.

The Unusual Suspect: A Case of Non-occlusive Mesenteric Ischemia in a Patient With Cirrhosis.

Acute mesenteric ischemia has a variety of etiologies. Non-occulusive mesenteric ischemia accounts for 20-30% of patients with acute mesenteric ischemia. We describe a case of non-occulusive jejunal ischemia leading to infarction that occurred in a patient with cirrhosis and no previous history of cardiovascular disease.

Resolution of hereditary hemorrhagic telangiectasia and anemia with prolonged alpha-interferon therapy for chronic hepatitis C.

Hereditary hemorrhagic telangiectasia is a group of autosomal dominant disorders, characterized by telangiectases that develop in the skin, mucous membranes, and visceral organs. Currently, there is no satisfactory treatment of hereditary hemorrhagic telangiectasia. Interferon has never been used for the treatment of hereditary hemorrhagic telangiectasia.

Role of fresh frozen plasma infusion in correction of coagulopathy of chronic liver disease: a dual phase study.

Objective: Fresh frozen plasma infusions are commonly used to correct the prolonged prothrombin time in patients with advanced chronic liver disease. The aim of this study was to establish how frequently this treatment is effective in correcting this coagulopathy.

Methods: A split retrospective-prospective study design was employed.

The liver in other (nondiabetic) endocrine disorders.

The liver has a major role in the proper maintenance of intermediate metabolism and endocrine homeostasis. It contains enzymes that are essential for hormonal biotransformation and the regulation of numerous metabolic reactions, which control hormone metabolism. The liver also manufactures several proteins, which carry circulating hormones to their effector sites.

Steatohepatitis in obese individuals.

Nonalcoholic steatohepatitis (NASH), which is the most severe histological form of nonalcoholic fatty liver disease (NAFLD), is emerging as the most common clinically important form of liver disease in developed countries. Although its prevalence is 3% in the general population, this increases to 20-40% in obese patients. Since NASH is associated with obesity, prevalence has been predicted to increase along with the arsent epidemic of obesity and type II diabetes mellitus.

Connective tissue diseases and the liver.

Connective tissue diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjögren's syndrome, and scleroderma are systemic disorders that may have an autoimmune basis. The system manifestations vary, and there is frequent overlap among the syndromes. Liver involvement in patients with connective tissue diseases has been well documented but is generally considered rare.

Diabetes mellitus, obesity, and hepatic steatosis.

Nonalcoholic fatty liver disease is emerging as the most common liver disease in North America. The histological spectrum of nonalcoholic fatty liver disease ranges from fatty liver alone to steatohepatitis and to the most serious form--nonalcoholic steatohepatitis (NASH). An increasing body of evidence suggests that NASH is associated with the development of progressive fibrosis and eventually cirrhosis in approximately 20% of cases.