Publications by authors named "Wael Mohamed"

The removal of heavy metals, such as lead, from industrial wastewater is imperative due to their detrimental effects on both human health and the environment. This study delves into investigating the feasibility of employing a novel adsorbent, specifically a silica/klucel nanocomposite, for effectively extract lead from industrial effluents. The synthesis of this nanocomposite involved a simple and cost-effective method, combining silica nanoparticles with klucel.

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Introduction: Adult zebrafish are increasingly used in Parkinson's disease (PD) research due to their well-characterized dopaminergic system. Among the toxin-based models, the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely utilized to induce parkinsonism in adult zebrafish. Therefore, this review presents an overview of the procedures and the dynamic changes in behavior and physiology observed in the adult zebrafish PD model following a single intraperitoneal injection of MPTP.

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Article Synopsis
  • Over 80% of genetic studies on Parkinson's disease focus on individuals of European descent, highlighting a gap in understanding the disease across diverse global populations.
  • Environmental and genetic factors influencing PD vary by ancestry, emphasizing the need for worldwide research initiatives to identify new genes and risk factors involved in the disease.
  • The article reviews the limited genetic research on Parkinson's disease in AfrAbia, pointing out existing gaps and challenges while discussing historical interactions and clinical aspects of the disease in this population.
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Despite extensive preclinical research over the years, a significant gap remains in our understanding of the specific effects of methamphetamine (METH) and amphetamine (AMPH) withdrawal. Understanding these differences could be pivotal to unveiling the unique pathophysiology underlying each stimulant. This may facilitate the development of targeted and effective treatment strategies tailored to the specific characteristics of each substance.

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This paper presents a comprehensive exploration of a hybrid energy system that integrates wind turbines with photovoltaics (PVs) to address the intermittent nature of electricity production from these sources. The necessity for such technology arises from the sporadic nature of electricity generated by PV cells and wind turbines. The envisioned outcome is an emissions-free, more efficient alternative to traditional energy sources.

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  • Gastrointestinal bleeding (GIB) is frequent in patients with left ventricular assist devices (LVADs), but the best screening method before implantation is not well defined.
  • A study at Saint Luke's Hospital analyzed data from 167 LVAD patients, revealing that pre-implantation endoscopic evaluations showed a high occurrence of angiodysplasia but did not reduce overall GIB rates.
  • The findings support avoiding routine pre-LVAD endoscopic screening, advocating for individualized assessments based on each patient’s circumstances instead.
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  • - The study compared the adequacy of tissue samples for molecular testing in pancreatic cancer obtained through endoscopic ultrasound (EUS) fine-needle aspiration (FNA) and fine-needle biopsy (FNB) methods at Saint Luke's Hospital from 2018 to 2021.
  • - Out of 132 patients, FNB samples were significantly more adequate for molecular (71.4%) and genomic testing (46.4%) compared to FNA samples (32.1% and 23.8%, respectively).
  • - The number of passes needed for effective diagnosis was similar for both methods, but FNB proved to be more effective overall for achieving suitable samples for molecular testing, highlighting the importance of tumor surface area and cellular
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Mood disorders, including depression and anxiety, affect almost one-fifth of the world's adult population and are becoming increasingly prevalent. Mutations in circadian clock genes have previously been associated with mood disorders both directly and indirectly through alterations in circadian phase, suggesting that the circadian clock influences multiple molecular pathways involved in mood. By targeting previously identified single nucleotide polymorphisms (SNPs) that have been implicated in anxiety and depressive disorders, we use a combination of statistical and machine learning techniques to investigate associations with the generalized anxiety disorder assessment (GAD-7) scores in a UK Biobank sample of 90,882 individuals.

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Objectives To evaluate and compare different polygenic risk score (PRS) models in predicting Parkinsons disease (PD) across diverse ancestries, focusing on identifying the most suitable approach for each population and potentially contributing to equitable advancements in precision medicine. Methods We constructed a total of 105 PRS across individual level data from seven diverse ancestries. First, a cross-ancestry conventional PRS comparison was implemented by utilizing the 90 known European risk loci with weighted effects from four independent summary statistics including European, East Asian, Latino/Admixed American, and African/Admixed.

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Unlabelled: Alzheimer's disease (AD) is a devastative disease, the 1 most frequent neurodegenerative disease worldwide. Its prevalence is increasing and early detection methods as well as potential genomic based therapeutics are urgently needed.

Objectives: To better characterize recent seq studies of AD and site recent relevant literature.

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  • This study examines the behavior of non-functioning pituitary adenomas (NFPA) after endonasal surgery and suggests a cost-effective follow-up plan for patients.
  • The research analyzed data from 116 patients over an average follow-up period of 78.5 months, finding a strong correlation between tumor size after surgery and subsequent growth.
  • It proposes a new MRI follow-up regimen that could save patients over 300 £ on scan costs while helping to better schedule monitoring for tumor progression.
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Rhino sinusitis, is a common inflammatory disease that affects the nasal cavity and paranasal sinuses in millions of individuals. Chronic sinusitis patients complain of a combination of nasal obstruction, rhinorrhea, post nasal drip and facial pain. To identify the risk factors of the recurrence of nasal polyps in chronic rhino sinusitis patients after endoscopic sinus surgery.

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Background: Paraquat (1,1'-dimethyl-4-4'-bipyridinium dichloride) exposure is well-established as a neurotoxic agent capable of causing neurological deficits in offspring. This study aimed to investigate therapeutic effects of L. aqueous extract (AU) against paraquat (PQ) exposure.

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Parkinson's disease may be caused by a single highly deleterious and penetrant pathogenic variant in 5-10% of cases (monogenic). Research into these mutational disorders yields important pathophysiological insights. This article examines the phenotype, genotype, pathophysiology, and geographic and ethnic distribution of genetic forms of disease.

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Gastric glomus tumor is a rare mesenchymal tumor of the gastrointestinal tract, accounting for approximately 1% of all gastrointestinal soft tissue tumors. We describe a unique case of a 27-year-old female patient who presented with recurrent episodes of overt gastrointestinal bleeding requiring multiple blood transfusions. The patient was diagnosed with a gastric ulcer detected on esophagogastroduodenoscopy (EGD), which was grossly suggestive of an ulcerated gastrointestinal stromal tumor (GIST).

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Background: Parkinson's disease (PD), the most prevalent motoric neurodegenerative disease, has been intensively studied to better comprehend its complicated pathogenesis. Chronic neuroinflammation is a major factor contributing to the development of PD. Reportedly, high-mobility group box 1 (HMGB1) protein is capable of mediating neuroinflammatory response.

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High-mobility group box 1 (HMGB1) has been implicated as a key player in two critical factors of Parkinson's disease (PD): mitochondrial dysfunction and neuroinflammation. However, the specific role of HMGB1 in PD remains elusive. We investigated the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration on mitochondrial dysfunction and HMGB1-associated inflammatory genes as well as locomotor activity in zebrafish, aiming to elucidate the role of HMGB1 in PD.

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Introduction: Stress and infertility form a complex relationship. In line with this, various stress-related biological markers have been investigated in infertility.

Methods: This systematic review was performed using PRISMA guidelines (i) to report whether cortisol is highly present in infertile patients compared to fertile control; (ii) to report whether there is any significant difference in the cortisol level in infertile subjects that conceive and those that didn't at the end of assisted reproduction treatments.

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Glia, which was formerly considered to exist just to connect neurons, now plays a key function in a wide range of physiological events, including formation of memory, learning, neuroplasticity, synaptic plasticity, energy consumption, and homeostasis of ions. Glial cells regulate the brain's immune responses and confers nutritional and structural aid to neurons, making them an important player in a broad range of neurological disorders. Alzheimer's, ALS, Parkinson's, frontotemporal dementia (FTD), and epilepsy are a few of the neurodegenerative diseases that have been linked to microglia and astroglia cells, in particular.

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