Publications by authors named "Wael Abdou Hassan"
Ulcerative colitis (UC), a chronic autoimmune disease of the gut with a relapsing and remitting nature, considers a major health-care problem. DSS is a well-studied pharmacologically-induced model for UC. Toll-Like Receptor 4 (TLR4) and its close association with p-38-Mitogen-Activated Protein Kinase (p-38 MAPK) and nuclear factor kappa B (NF-κB) has important regulatory roles in inflammation and developing UC.
View Article and Find Full Text PDFColorectal cancer (CRC) is the most preventable malignancy globally, with a high mortality rate. Cancer stem cells (CSCs) are found previously in multiple types of cancer; CRC is one of them, and it has been correlated with several biomarkers. The two most essential markers related to colorectal CSCs are CD44 and CD133, which play a significant role in diagnosis, treatment, and prognosis.
View Article and Find Full Text PDFArticle Synopsis
- Most studies on carbimazole-induced testicular injury have been conducted on healthy animals, limiting their relevance to humans.
- Metformin was tested alongside carbimazole in a rat study to assess its effects on testicular health and thyroid function, showing that higher doses of Metformin helped improve various testicular functions.
- The findings suggest that Metformin can provide protective benefits to testicular health in conditions with thyroid issues, indicating a need for further research on this relationship in diabetic patients.
Background: The roles of c-KIT and HER2 protein expression in bladder cancer are still debated, and the prognostic value of these proteins as markers of tumor progression is inconclusive.
Objective: To assess the impact of HER2 and c-KIT protein expressions in the progression of non-muscle-invasive bladder cancer.
Methods: All patients undergoing transurethral resection of bladder tumors for non-muscle-invasive urothelial carcinoma, with standard regimen of BCG, between January 2017 and November 2019, were evaluated pathologically and immunohistochemically for HER1 and c-KIT proteins in urothelial carcinoma cells.