A new flavonolignan from milk thistle ().

A new flavonolignan, sonyamandin , along with other known compounds was isolated from the aerial parts and seeds extracts of (milk thistle) collected from Jordan. The known ones are ursolic acid , oleanolic acid , maslinic acid oleic acid , β-sitosterol , β-, sitosteryl glucoside apigenin , kaempferol-3-O-rhamnoside , apigenin-7-O-β-D-glycoside , isosylibin A , isosylibin B and silybin B . The absolute stereochemistry of was confirmed by 2D NMR and CD analysis.

Studies on Selected Jordanian Plants as Dipeptidyl Peptidase-IV Inhibitors for Management of Diabetes Mellitus.

Diabetes mellitus is a chronic disease characterized by hyperglycemia mainly because of the absolute or relative deficiency of insulin hormone. The dipeptidyl peptidase-IV inhibitors represent a class of glucose-lowering agents potentiating the action of the incretin hormones glucagon-likepeptide-1 and glucose dependent insulinotropic polypeptide, which are secreted from the intestinal endocrine cells in response to food ingestion to stimulate insulin secretion from pancreatic beta cells. Natural products have been traditionally used for curing many diseases.