Embedded sharp metallic spring in esophagus.

Less than 1% of esophageal foreign bodies are irretrievable by endoscopic techniques. These cases require esophagotomy for removal. The impacted metallic spring with sharp ends (in opposite direction) is reported as esophageal foreign body which required esophagotomy after two failed endoscopic removals.

Cholelithoptysis: a rare complication of laparoscopic cholecystectomy.

Two months after laparoscopic cholecystectomy, a 54-year-old man presented for medical care with cholelithoptysis (the coughing up of gallstones). This rare complication was managed without a further operation. Possible mechanisms and preventive measures are discussed.

Effect of centchroman on tubal transport and preimplantation embryonic development in rats.

A single oral administration of centchroman (1.25 mg/kg) to adult female rats within 24 h of mating induced slight acceleration in the rate of transport of embryos through the oviducts. The compound did not seem to produce any deleterious effect on preimplantation embryonic development since well organized and apparently normal embryos were collected from the genital tract up to Day 12 of pregnancy.

Carbohydrate metabolism in the genital organs of adult female rhesus monkeys: effect of prolonged treatment with centchroman, an antiimplantation agent.

Weekly oral administration of centchroman at 1 and 2.5 mg/kg doses for 3, 6 or 12 months to adult female rhesus monkeys (Macaca mulatta) significantly decreased glycogen content and activity of phosphorylase, glucokinase, lactate dehydrogenase and glucose 6-phosphate dehydrogenase enzymes in all the genital tract tissues. In general, the inhibition was dose and time dependent.

Viability and development of 'tube-locked' mouse embryos.

'Tube-locked' morulae and blastocysts were recovered from the ampulla of the oviduct of centchroman-treated mice between Days 4 and 12 post coitum and transferred to the uteri of pseudopregnant female mice. Pregnancy and implantation rates were lower and the post-implantation resorption rate was higher in the treated than in the control group. There was little difference in the pregnancy or implantation rates between embryos recovered on Days 4 or 12 post coitum, but the resorption rate increased with increasing duration of embryos in the oviducts and was 100% for the Day-12 embryos.