Publications by authors named "Wade Wei-Ting Kuo"
Background/aim: The role of nuclear respiratory factor 1 (NRF1) on the prostate cancer progression is controversial. We aimed to investigate the effect of NRF1 overexpression on the metastasis potential of PC3 prostate cancer cells and the associated molecular mechanisms.
Materials And Methods: Cell survival, migration capacity, mitochondrial biogenesis, the expression of TGF-β signaling and EMT markers were examined after overexpression and silencing of NRF1 in PC3 cells.
Article Synopsis
- Enzalutamide is a treatment for castration-resistant or metastatic prostate cancer, but many patients eventually become resistant to it; this study focuses on the role of N-cadherin (CDH2) in this resistance.
- The research investigated how upregulating and downregulating CDH2 expression affected the LNCaP prostate cancer cell line, particularly in terms of cell viability and migratory ability.
- Results indicated that increased CDH2 expression in enzalutamide-resistant LNCaP cells enhanced their viability and migration, suggesting that targeting CDH2 could be a promising therapeutic approach for treating resistant prostate cancer.
Introduction: Prostate cancer has significant mortality and metastasis rate in the male. Unfortunately, effective treatment for patients with advanced prostate cancer is still lacking. Verbascoside, a phenylethanoid glycoside, displays various pharmacological properties, such as the anti-cancer activities.
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