Risk factors for clinically significant importance of shape and weight in adolescent girls.

The objective of the current study was to conduct a longitudinal study of adolescent girls to determine how temperament, attitudes toward shape and weight, life events, and family factors might contribute to the growth of clinically significant importance of shape and weight, assessed using the Eating Disorder Examination (EDE). Time 1 data were available from 699 female twins (M age = 13.96 years) and 595 parents, and approximately 1.

Age differences in genetic and environmental influences on weight and shape concerns.

Objective: Previous research has shown important developmental shifts ingenetic and environmental influences for disordered eating. However, little research has examined age differences for weight/shape concerns, two key components of eating disorders. The goal of this study was to investigate these age differences in preadolescent, adolescent, young adult, and mid-adult twins.

Arterial distensibility is reduced in overweight pre- and early pubescent children.

The objective of this study was to examine the differences in arterial distensibility between overweight/obese and normal weight pre- and early pubescent boys and girls. Arterial distensibility was measured in 65 children (43 normal weight and 22 overweight/obese) between the ages of 9 and 12 years. Weight classification was based on age and sex-specific body mass index (BMI) cut-offs and pubertal maturation by Tanner staging.

A randomized controlled trial of brief interventions for body dissatisfaction.

The authors examined the relative effectiveness of 3 different approaches to the experience of body dissatisfaction compared to a control and ruminative attention control condition, with respect to increasing weight and appearance satisfaction. One hundred female undergraduates (mean age = 24.38, SD = 9.

The Sonoma water evaluation trial: a randomized drinking water intervention trial to reduce gastrointestinal illness in older adults.

Objectives: We estimated the relative rate of highly credible gastrointestinal illness (HCGI) per year associated with active versus sham household water filtration devices among older adults in a community receiving tap water meeting current US standards.

Methods: We conducted a randomized, triple-blinded, crossover trial in 714 households (988 individuals), which used active and sham water filtration devices for 6 months each. We estimated the annual incidence rate ratio of HCGI episodes and the longitudinal prevalence ratio of HCGI days at population and individual levels with a generalized estimating equation (GEE) and generalized linear mixed models (GLMMs), respectively, adjusted for covariates associated with outcome.

Adipokines and cytokines in human pancreatic juice: unraveling the local pancreatic inflammatory milieu.

Background: Differential adipokine expression in obesity influences the inflammatory milieu, and may explain in part obesity's negative impact on pancreatic disease. Pancreatic juice analysis may provide a good means to evaluate the local pancreatic inflammatory milieu. The presence of adipokines in pancreatic juice is unknown.

Transitions in hearing impairment and psychological distress in older adults.

Objective: Although previous research has demonstrated an association between hearing impairment (HI) and psychological distress, less work has explored the effect of transitions in hearing status on distress over time, or the explanatory pathways that may explain this association.

Method: We use 2 waves of data from the Canadian National Population Health Survey to examine the effect of HI transitions on changes in distress during 6 years, and to test the potential mediating effects of psychosocial factors and chronic stressors.

Results: Experiencing a decline in hearing was associated with increased distress at Wave 4, net of Wave 1 distress, although the significance of the relation was reduced to trend level following adjustment for sociodemographic variables (P < 0.

Impact of school-based health centers on students with mental health problems.

Objectives: School-based health centers (SBHCs) play an increasingly major role in providing mental health services for students. This study evaluated the impact of SBHCs on mental health-care services and psychosocial health-related quality of life (HRQOL).

Methods: Four SBHC intervention and two matched non-SBHC school districts were examined from 1997 to 2003.

Access and utilization patterns of school-based health centers at urban and rural elementary and middle schools.

Objective: We examined patterns of enrollment, use, and frequency of use in school-based health centers (SBHCs), as well as the referral, diagnosis, and disposition of SBHC visits among newly implemented SBHCs.

Methods: Four rural and four urban school districts implementing SBHCs were examined from 2000 to 2003. Total school enrollment for students was 13,046.

Elevated ERCC1 gene expression in blood cells associated with exposure to arsenic from drinking water in Inner Mongolia.

Background: Chronic arsenic exposure has been associated with human cancer. The objective of this study was to investigate the effects of arsenic exposure on a DNA nucleotide excision repair gene, ERCC1, expression in human blood cells.

Patients And Methods: Water and toenail samples were collected from a total of 327 Inner Mongolian residents for arsenic analysis.

Modeling Enterococcus densities measured by quantitative polymerase chain reaction and membrane filtration using environmental conditions at four Great Lakes beaches.

Data collected by the US Environmental Protection Agency (EPA) during the summer months of 2003 and 2004 at four US Great Lakes beaches were analyzed using linear regression analysis to identify relationships between meteorological, physical water characteristics, and beach characteristics data and the fecal indicator bacteria, Enterococcus. Water samples were analyzed for Enterococcus densities by quantitative polymerase chain reaction (qPCR) and membrane filtration (MF). This paper investigates the ability of regression models to accurately predict Enterococcus densities above or below a threshold value, using environmental data on a beach-by-beach basis for both methods.

Obesity potentiates the growth and dissemination of pancreatic cancer.

Background: Obesity is an independent risk factor for pancreatic cancer development and progression, although the mechanisms underlying this association are completely unknown. The aim of the current study was to investigate the influence of obesity on pancreatic cancer growth using a novel in vivo model.

Methods: Lean (C57BL/6 J) and obese (Lep(Db) and Lep(Ob)) mice were inoculated with murine pancreatic cancer cells (PAN02), and studied after 5 weeks of tumor growth.

Contact with beach sand among beachgoers and risk of illness.

Recent studies of beach sand fecal contamination have triggered interest among scientists and in the media. Although evidence shows that beach sand can harbor high concentrations of fecal indicator organisms, as well as fecal pathogens, illness risk associated with beach sand contact is not well understood. Beach visitors at 7 US beaches were enrolled in the National Epidemiological and Environmental Assessment of Recreational Water (NEEAR) Study during 2003-2005 and 2007 and asked about sand contact on the day of their visit to the beach (digging in the sand, body buried in the sand).

Acoustic characteristics of clearly spoken English fricatives.

Speakers can adopt a speaking style that allows them to be understood more easily in difficult communication situations, but few studies have examined the acoustic properties of clearly produced consonants in detail. This study attempts to characterize the adaptations in the clear production of American English fricatives in a carefully controlled range of communication situations. Ten female and ten male talkers produced fricatives in vowel-fricative-vowel contexts in both a conversational and a clear style that was elicited by means of simulated recognition errors in feedback received from an interactive computer program.

Reduction of shape and weight concern in young adolescents: a 30-month controlled evaluation of a media literacy program.

Objective: Recent eating disorder prevention efforts have targeted high-risk females in late adolescence (>15 years). Methodologically rigorous evaluations of prevention programs directed to younger, mixed-sex, universal audiences are largely absent. The primary objective was to evaluate a theoretically informed media literacy program delivered to a mixed-sex, universal, young adolescent audience.

A method for comparative analysis of recovery potential in impaired waters restoration planning.

Common decision support tools and a growing body of knowledge about ecological recovery can help inform and guide large state and federal restoration programs affecting thousands of impaired waters. Under the federal Clean Water Act (CWA), waters not meeting state Water Quality Standards due to impairment by pollutants are placed on the CWA Section 303(d) list, scheduled for Total Maximum Daily Load (TMDL) development, and ultimately restored. Tens of thousands of 303(d)-listed waters, many with completed TMDLs, represent a restoration workload of many years.

Nuclear magnetic resonance spectroscopy-based metabolomics of the fatty pancreas: implicating fat in pancreatic pathology.

Background: Obesity is a worldwide epidemic and a significant risk factor for pancreatic diseases including pancreatitis and pancreatic cancer; the mechanisms underlying this association are unknown. Metabolomics is a powerful new analytical approach for describing the metabolome (compliment of small molecules) of cells, tissue or biofluids at any given time. Our aim was to analyze pancreatic fat content in lean and congenitally obese mice using both metabolomic analysis and conventional chromatography.

Corrected and uncorrected hearing impairment in older Canadians.

Background: Hearing impairment (HI) is a common chronic condition in later life, but one that can often be improved with the use of a hearing aid. However, a distinction is not often made between corrected and uncorrected HI in the literature.

Objective: To estimate the prevalence of corrected and uncorrected HI, and assess whether there are differences in sociodemographic factors among older adults (age 50+) with corrected HI, uncorrected HI and no HI.

Increased mortality associated with well-water arsenic exposure in Inner Mongolia, China.

We conducted a retrospective mortality study in an Inner Mongolian village exposed to well water contaminated by arsenic since the 1980s. Deaths occurring between January 1, 1997 and December 1, 2004 were classified according to underlying cause and water samples from household wells were tested for total arsenic. Heart disease mortality was associated with arsenic exposure, and the association strengthened with time exposed to the water source.

Well water arsenic exposure, arsenic induced skin-lesions and self-reported morbidity in Inner Mongolia.

Residents of the Bayingnormen region of Inner Mongolia have been exposed to arsenic-contaminated well water for over 20 years, but relatively few studies have investigated health effects in this region. We surveyed one village to document exposure to arsenic and assess the prevalence of arsenic-associated skin lesions and self-reported morbidity. Five-percent (632) of the 12,334 residents surveyed had skin lesions characteristics of arsenic exposure.

Elevated human telomerase reverse transcriptase gene expression in blood cells associated with chronic arsenic exposure in Inner Mongolia, China.

Background: Arsenic exposure is associated with human cancer. Telomerase-containing human telomerase reverse transcriptase (hTERT) can extend telomeres of chromosomes, delay senescence, and promote cell proliferation leading to tumorigenesis.

Objective: The goal of this study was to investigate the effects of As on hTERT mRNA expression in humans and in vitro.

Changes over time in physical activity and psychological distress among older adults.

Objective: While previous research has established that regular involvement in physical activity (PA) is associated with better mental health in old age, the socio-cognitive factors that mediate the association have only been partially tested. We examined whether changes in PA are associated with changes in distress during a 6-year period, and whether this association is mediated by changes in global self-esteem, mastery, and physical health status.

Method: A residualized regression technique was used to examine changes over time in a national longitudinal survey of adults aged 65 years and older (n = 1327).

A prospective examination of perceived stress as a mediator of the relationship between life-events and QOL following breast cancer.

Objectives: This study prospectively investigated the relationship between life-events, perceived stress, and quality of life (QOL) following breast cancer diagnosis, using the bio-behavioural model of cancer stress as a framework.

Design: A longitudinal, self-report design was used.

Methods: Three waves of data from 10,543 mid-aged Australian women (aged 45-50 at Survey 1) were collected over 5 years as part of a population-based survey.