Biomechanical properties of novel biodegradable poly ε-caprolactone-chitosan scaffolds.

Aim: To investigate the biomechanical properties of poly ε-caprolactone (PCL)-chitosan (CS) scaffolds fabricated by the melt stretching and multilayer deposition technique.

Methods: The PCL-CS scaffolds containing CS at 0% (pure PCL), 10%, and 20% by weight were prepared. For the monolayer scaffolds, shear and blending tests simulating the reconstruction of orbital floor defects (situation A) and mandibular defects (situation B) were conducted.

Biodegradable polycaprolactone-chitosan three-dimensional scaffolds fabricated by melt stretching and multilayer deposition for bone tissue engineering: assessment of the physical properties and cellular response.

Fabrication of polycaprolactone (PCL)-chitosan (CS) three-dimensional (3D) scaffolds using the novel technique of melt stretching and multilayer deposition was introduced. In brief, firstly, the PCL-CS monofilaments containing 0% (pure PCL), 10%, 20% and 30% CS by weight were fabricated by melting and stretching processes. Secondly, the desired multilayer (3D) scaffolds were fabricated by arranging and depositing the filaments.