Publications by authors named "Wa Cheong Chan"
Article Synopsis
- A study investigated the relationship between genetic variants associated with asthma and lung function using data from asthmatic children and adults, focusing on eight identified single-nucleotide polymorphisms (SNPs).
- The results indicated that specific SNPs, such as GSDMB_rs2305480 and IL13_rs1295686, are significantly linked to different forms of asthma and lung function metrics, including FEV1 and FVC.
- The research concluded that certain genes (IL13, GSDMB) not only play a role in asthma susceptibility but also interact with other genes to impact lung function measurements in both children and adults.
Background: Childhood asthma is caused by both genetic and environmental factors. The first genomewide association study (GWAS) for asthma revealed putative candidates on nine chromosomal regions in Caucasians, with 17q21 locus being the most widely replicated one. However, there was no replication study for the other loci.
View Article and Find Full Text PDF