[The role of radiotherapy in the treatment of granuloma gangraenescens (lethal midline granuloma].

The granuloma gangraenescens in the oral, maxillary and facial region is a rare disease. It is a destroying process in the region of palate, nose, paranasal sinuses, cheeks and orbit with characteristic signs of granulomatosis, infection and malignancy. The disease shows often a lethal development with cachexia or sepsis.

[Mass data and psychoacoustic interpretations of patients with 8-channel cochlear implants (author's transl)].

Six patients are described following insertion of an 8-channel cochlear implant. The prosthesis was modified from the Vocoder technique, and was implanted by a simplified method of the procedure previously reported by us. In addition to the perception of background noise as well as the differentiation of periodicity and frequencies, a distinct improvement of the patients' speech discriminations could be observed with this technique.

Vidian neurectomy: neuroanatomical considerations and a report on a new surgical approach.

If conventional treatment fails, vidian neurectomy is a viable alternative for therapy of chronic rhinitis with recurrent polyposis of the nose and sinuses. From a neuroanatomical point of view beneficial and adverse effects of this surgical procedure are discussed. According to our own investigations and experiences, vidian neurectomy should be performed together with clearing out of the sinuses in every case.

[First observations of a cochlear-implant operation (author's transl)].

We report on our observations following our first cochlear-implant operation in a patient, and have found that the implantation of a single electrode can allow the patient to realize background noise.

Nasopharyngeal and adjacent neoplasms: a clinico-pathologic and immunologic study.

Thirteen cases of nasopharyngeal carcinoma (NPC) and 16 cases of non-NPC tumors in the nasopharynx or in adjacent locations were investigated clinically, immunologically, and pathologically. All tumors were classified according to the TNM classification, and the stage and course of the disease was correlated with the histological tumor type, the T- and B-cell distribution in tumor tissue and in the peripheral blood, as well as with antibody titers against Epstein-Barr virus (EBV). The results showed a positive correlation of decreased T- and B-cells in tumor tissue and of decreased T-cells in the peripheral blood with the extend of the tumor in both NPC and non-NPC cases, with some exceptions of lymphocyte rich neoplasms (lymphoepithelial carcinoma and malignant lymphoma).

[Classification of malignant lymphomas of the neck: combined morphological, immunocytological, serological and tissues culture studies (author's transl)].

81 untreated malignant lymphomas of the neck were classified morphologically according to the German Kiel classification and to the American classification of Rappaport and Berard and these tumors were typed immunologically as to their T- or B-cell nature. Cells from 16 of these patients were subsequently grown in tissue culture for periods up to seven months. Tissue culture cells were monitored as to spontaneous variations in the morphologic cell type and to the expression of T- or B-cell surface determinants.

[Percent distribution of B-Lymphocytes in human tonsils at various ages].

B-Lymphocytes of the classes G, M and A were determined by use of heavy-chain-specific fluorescent antisera from 67 children between 2 and 14 years of age and from 15 adults up to 60 years of age. Tonsils from which viable cell suspensions were investigated for B-Cells were classified histologically, according to their degree of lymphatic hyperplasia and inflammation. With increasing age, a statiscally significant decrease in percent G- and M-cells was observed while A-cells remained unchanged.

[Membrane receptors of lymphoreticular cells in hyperplastic and neoplastic diseases of the lymphatic system].

The results of T- and B-cell determinations are described in 105 cases of lymphoreticular and lymphoepithelial neoplasia, and are compared to similar investigations of 582 cases as published in the literature. In addition, T- and B-cell values are determined in blood of 35 healthy individuals, in 12 normal lymph nodes, as well as in hyperplastic conditions of lymph nodes from 30 patients and of tonsils from 85 patients. Cell characterizations are done by immunofluorescence and use of monospecific anti-immunoglobulin antisera (H chain specific), anti-thymus antiserum, as well as by the E-rosette test.

[The distribution of B-lymphocytes in lymphoepithelial tissues as well as in tumors of the neck-, nose-, and throat region derived from lymphoreticular and lymphoepithelial tissues (author's transl)].

B-Lymphocytes carrying IgG-, IgM,- and IgA-surface receptors were estimated by fluorescence microscopy in the palatine tonsil of 50 patients aged 3 to 18 years as well as in 44 patients with various types of malignant lymphoms and lymphoepithelial carcinomas. Hyperplastic tonsillartissue contains large numbers of B-cells with a marked variability in concentration (4-30% IgG-cells, medium 12,9%;6-36 IgM-cells, medium 23.4%;3-38% IgA cells, medium 20.