Text Messages Exchanged Between Individuals With Opioid Use Disorder and Their mHealth e-Coaches: Content Analysis Study.

Background: Opioid use disorder (OUD) has affected 2.2 million people in the United States. About 7.

Culpability Framing Influences on Community Support for Those Managing Illness: A Multi-Malady Comparison of Mediated Health Stigma.

Prior research demonstrates an influence of culpability framing on news consumers' perceptions about, and willingness to provide support for, those managing illness. Framing research of this sort has typically focused on the effect of frames on a particular health context (e.g.

A Meta-Analysis of Case Fatality Rates of Recurrent Venous Thromboembolism and Major Bleeding in Patients with Cancer.

Background:  Knowing the case fatality rates of recurrent venous thromboembolism (VTE) and major bleeding is important for weighing the relative risks and benefits of anticoagulation and deciding on the duration of anticoagulant therapy, but these rates are uncertain in patients with cancer-associated thrombosis.

Methods:  We performed a systematic review and a meta-analysis to determine the incidence of recurrent VTE and major bleeding and their respective case fatality rates in patients with cancer-associated VTE.

Results:  Our analysis included 29 studies (15 prospective cohort studies and 14 randomized controlled trials) from 1980 to January 2019.

Large potential reduction in economic damages under UN mitigation targets.

International climate change agreements typically specify global warming thresholds as policy targets , but the relative economic benefits of achieving these temperature targets remain poorly understood. Uncertainties include the spatial pattern of temperature change, how global and regional economic output will respond to these changes in temperature, and the willingness of societies to trade present for future consumption. Here we combine historical evidence with national-level climate and socioeconomic projections to quantify the economic damages associated with the United Nations (UN) targets of 1.

Stigma associated with sexually transmissible infection testing in an online testing environment: examining the perspectives of youth in Vancouver, Canada.

Unlabelled: Background Online sexually transmissible infection (STI) testing is increasingly available and has shown promising results across different settings. However, evidence on how stigma associated with STI testing may be experienced by youth in the context of these online services is limited.

Methods: A convenience sample of 71 youth (aged 15-24 years) both male and female was engaged through online and offline recruitment strategies in Vancouver, Canada.

Combining satellite imagery and machine learning to predict poverty.

Reliable data on economic livelihoods remain scarce in the developing world, hampering efforts to study these outcomes and to design policies that improve them. Here we demonstrate an accurate, inexpensive, and scalable method for estimating consumption expenditure and asset wealth from high-resolution satellite imagery. Using survey and satellite data from five African countries--Nigeria, Tanzania, Uganda, Malawi, and Rwanda--we show how a convolutional neural network can be trained to identify image features that can explain up to 75% of the variation in local-level economic outcomes.

Medical linear accelerator mounted mini-beam collimator: design, fabrication and dosimetric characterization.

The goal of this work was to design, build and experimentally characterize a linear accelerator mounted mini-beam collimator for use at a nominal 6 MV beam energy. Monte Carlo simulation was used in the design and dosimetric characterization of a compact mini-beam collimator assembly mounted to a medical linear accelerator. After fabrication, experimental mini-beam dose profiles and central axis relative output were measured and the results used to validate the simulation data.

Nano-fEM: protein localization using photo-activated localization microscopy and electron microscopy.

Mapping the distribution of proteins is essential for understanding the function of proteins in a cell. Fluorescence microscopy is extensively used for protein localization, but subcellular context is often absent in fluorescence images. Immuno-electron microscopy, on the other hand, can localize proteins, but the technique is limited by a lack of compatible antibodies, poor preservation of morphology and because most antigens are not exposed to the specimen surface.

Young people's perspectives on the use of reverse discourse in web-based sexual-health interventions.

Web-based sexual-health promotion efforts often utilise reverse discourse - the acknowledgement and rejection of shame associated with stigmatised terms - both to challenge judgments about 'risky' behaviours (e.g., casual sex) and to appeal to young people.

Pyrolysis products of linear alkylbenzenes--implications in fire debris analysis.

In this case report, potential interferences from an improvised fire-extinguishing agent, a dishwashing liquid, containing linear alkylbenzene sulfonates (LAS), was studied. The presence of linear alkylbenzenes (LABs) in the fire debris sample was identified from the summed ion profile (SIP) analysis. It was found that the LAS from dishwashing liquids produce LABs by thermal degradation.

Organic nitriles from acid chlorides: an isovalent N for (O)CL exchange reaction mediated by a tungsten nitride complex.

Nitride NW(N[i-Pr]Ar)3 (1, Ar = 3,5-C6H3Me2) was synthesized in two steps from known NW(O-t-Bu)3 (41% overall yield). Complex 1 is the tungsten congener of NMo(N[i-Pr]Ar)3, a known molecule that has been synthesized using N2 as the nitrido nitrogen source, but which undergoes no reaction with pivaloyl chloride. Compound 1 undergoes metathesis with pivaloyl chloride at 25 degrees C to form the corresponding nitrile in 97% yield.

Molybdenum triamidoamine complexes that contain hexa-tert-butylterphenyl, hexamethylterphenyl, or p-bromohexaisopropylterphenyl substituents. An examination of some catalyst variations for the catalytic reduction of dinitrogen.

Three new tetramines, (ArNHCH(2)CH(2))(3)N, have been synthesized in which Ar = 3,5-(2,4,6-t-Bu(3)C(6)H(2))(2)C(6)H(3) (H(3)[HTBTN(3)N]), 3,5-(2,4,6-Me(3)C(6)H(2))(2)C(6)H(3) (H(3)[HMTN(3)N]), or 4-Br-3,5-(2,4,6-i-Pr(3)C(6)H(2))(2)C(6)H(2) (H(3)[pBrHIPTN(3)N]). The diarylated tetramine, [3,5-(2,4,6-t-Bu(3)C(6)H(2))(2)C(6)H(3)NHCH(2)CH(2)](2)NCH(2)CH(2)NH(2), has also been isolated, and the "hybrid" tetramine [3,5-(2,4,6-t-Bu(3)C(6)H(2))(2)C(6)H(3)NHCH(2)CH(2)](2)NCH(2)CH(2)NH(4-t-BuC(6)H(4)) has been prepared from it. Monochloride complexes, [(TerNCH(2)CH(2))(3)N]MoCl, have been prepared, as well as a selection of intermediates that would be expected in a catalytic dinitrogen reduction such as [(TerNCH(2)CH(2))(3)N]Mo[triple bond]N and [[(TerNCH(2)CH(2))(3)N]Mo(NH(3))][BAr'(4)] (Ter = HTBT, HMT, or pBrHIPT and Ar' = 3,5-(CF(3))(2)C(6)H(3))).

Copper(I) complexes of a heavily fluorinated beta-diketiminate ligand: synthesis, electronic properties, and intramolecular aerobic hydroxylation.

The aza-Wittig reaction between Ar(f)()-N=PPh(3) [Ar(f)() = 3,5-(CF(3))(2)C(6)H(3)] and 1,1,1,5,5,5-hexafluoro-2,4-pentanedione affords a new, highly fluorinated beta-diketimine, 1. Metalation by mesitylcopper(I) in benzene gives rise to the Cu(I) beta-diketiminate as its eta(2)-benzene adduct, 2a. Copper(I) carbonyl complexes of 1, and of three less-fluorinated analogues, have been generated in situ and compared by IR spectroscopy; the two backbone CF(3) groups exert a stronger electronic influence than the four N-aryl CF(3) groups.

Synthesis and reactions of molybdenum triamidoamine complexes containing hexaisopropylterphenyl substituents.

We have synthesized a triamidoamine ligand ([(RNCH(2)CH(2))(3)N](3)(-)) in which R is 3,5-(2,4,6-i-Pr(3)C(6)H(2))(2)C(6)H(3) (hexaisopropylterphenyl or HIPT). The reaction between MoCl(4)(THF)(2) and H(3)[HIPTN(3)N] in THF followed by 3.1 equiv of LiN(SiMe(3))(2) led to formation of orange [HIPTN(3)N]MoCl.

N-(2-Mercaptoethyl)picolylamine as a diaminomonothiolate ligand for the "fac-[Re(CO)3]+" core.

N-(2-Mercaptoethyl)picolylamine (MEPAH) was studied as a potentially biologically relevant ligand for the "fac-[M(CO)(3)](+)" core (M = Re, (99)Tc, (99m)Tc). To this end, the complex Re(CO)(3)(MEPA) was synthesized. The reaction of MEPAH with fac-[Re(CO)(3)(MeCN)(3)](+) took place over the course of seconds, showing the high affinity possessed by this ligand for the "fac-[Re(CO)(3)](+)" core.

Reduction of the pertechnetate anion with bidentate phosphine ligands.

The reduction of ammonium pertechnetate with bis(diphenylphosphino)methane (dppm), and with diphenyl-2-pyridyl phosphine (Ph(2)Ppy), has been investigated. The neutral Tc(II) complex, trans-TcCl(2)(dppm)(2) (1), has been isolated from the reaction of (NH(4))[TcO(4)] with excess dppm in refluxing EtOH/HCl. Chemical oxidation with ferricinium hexafluorophosphate results in formation of the cationic Tc(III) analogue, trans-[TcCl(2)(dppm)(2)](PF(6)) (2).

Synthesis and characterization of technetiumtetrakis(acetonitrile)bis(triphenylphosphine) cationic complexes.

A new route to low-valent technetium complexes containing multiple acetonitrile ligands has been developed. The reduction of TcCl(4)(PPh(3))(2) with zinc metal dust in acetonitrile results in the formation of [Tc(CH(3)CN)(4)(PPh(3))(2)][Zn(2)Cl(6)](1/2). The hexafluorophosphate salt of the analogous Tc(II) cation can be prepared via chemical oxidation of the Tc(I) species, and the Tc(I) cation can be regenerated via chemical reduction.

Atomic carbon as a terminal ligand: studies of a carbidomolybdenum anion featuring solid-state (13)C NMR data and proton-transfer self-exchange kinetics.

Anion [CMo(N[R]Ar)(3)](-) (R = C(CD(3))(2)CH(3) or (t)Bu, Ar = 3,5-C(6)H(3)Me(2)) containing one-coordinate carbon as a terminal substituent and related molecules have been studied by single-crystal X-ray crystallography, solution and solid-state (13)C NMR spectroscopy, and density functional theory (DFT) calculations. Chemical reactivity patterns for [CMo(N[R]Ar)(3)](-) have been investigated, including the kinetics of proton-transfer self-exchange involving HCMo(N[R]Ar)(3), the carbidomolybdenum anion's conjugate acid. While the Mo triple bond C bond lengths in [K(benzo-15-crown-5)(2)][CMo(N[R]Ar)(3)] and the parent methylidyne, HCMo(N[R]Ar)(3), are statistically identical, the carbide chemical shift of delta 501 ppm is much larger than the delta 282 ppm shift for the methylidyne.

The effects of nandrolone decanoate on cocaine-induced kindling in male rats.

Use and abuse of various controlled substances in recent years has reached alarming levels. Among these are cocaine and anabolic steroids. The two contrasting types of drug have common sites of action within the limbic system of the central nervous system.

Relationship of dopamine to serotonin in the neonatal 6-OHDA rat model of Lesch-Nyhan syndrome.

Rats were treated as neonates with either 6-hydroxydopamine (6-OHDA) 100 micrograms or vehicle intracisternally. Upon maturation, animals receiving 6-OHDA were assigned to four groups, with two of the four groups receiving intraventricular 5,7-dihydroxytryptamine (5,7-DHT) 75 micrograms bilaterally. At 94 days of age, animals were injected with either SKF-38393 (3.