An Indoor Gardening Planting Table Game Design to Improve the Cognitive Performance of the Elderly with Mild and Moderate Dementia.

The purpose of this study is to improve the overall cognitive function of patients with dementia in Yunlin County, Taiwan, by designing an indoor gardening flower combination game suitable for home and maintenance institutions. This paper uses qualitative research (participatory interviews, case studies, and contextual observation methods in the demand exploration phase) and quantitative research (experimental methods and the Mini-Mental State Examination (MMSE) and Barthel Index questionnaires in the product verification phase). This study adopted a four-stage service design: demand exploration, demand definition, design implementation, and product verification.

Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation.

Purpose: Vascular smooth muscle cell (VSMC) proliferation induced by native low-density lipoprotein (nLDL) stimulation is dependent on superoxide production from activated NADPH oxidase. The present study aimed to investigate whether the novel arginase inhibitor limonin could suppress nLDL-induced VSMC proliferation and to examine related mechanisms.

Materials And Methods: Isolated VSMCs from rat aortas were treated with nLDL, and cell proliferation was measured by WST-1 and BrdU assays.

TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response.

Despite advances in our understanding of protein kinase regulation in the DNA damage response, the mechanism that controls protein phosphatase activity in this pathway is unclear. Unlike kinases, the activity and specificity of serine/threonine phosphatases is governed largely by their associated proteins. Here we show that Tip41-like protein (TIPRL), an evolutionarily conserved binding protein for PP2A-family phosphatases, is a negative regulator of protein phosphatase 4 (PP4).

The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.

Glutamine is an essential nutrient for cancer cell survival and proliferation, yet the signaling pathways that sense glutamine levels remain uncharacterized. Here, we report that the protein phosphatase 2A (PP2A)-associated protein, α4, plays a conserved role in glutamine sensing. α4 promotes assembly of an adaptive PP2A complex containing the B55α regulatory subunit via providing the catalytic subunit upon glutamine deprivation.

Effects of cheiloplasty on maxillary dental arch development in infants with unilateral complete cleft lip and palate.

Objective: To identify and analyze quantitatively the development of the maxillary dental arch before and after cheiloplasty.

Design: Prospective, longitudinal study of maxillary dental arch development at age of 1, 3, 6, and 12 months.

Setting: All patients were treated at a university hospital craniofacial center.