Publications by authors named "WF Tseng"
Objectives: The aim of this article is to present the preliminary impact of a medication monitoring program, PharmaCloud, in Taiwan and analyze the embedded factors that have contributed to the performance thereof. This article also compared PharmaCloud with similar international programs in order to draw lessons learned.
Methods: The five domains of the RE-AIM framework - reach, effectiveness, adoption, implementation, and maintenance - were examined using qualitative and quantitative data.
Article Synopsis
- Researchers identified a specific genetic circuit, called a "kernel," that regulates endoderm development in zebrafish, which is conserved across many species.
- They studied the interactions between several key genes (gata5, gata6, otx2, and prdm1a) using various experimental techniques to confirm how these genes influence the specification of the endoderm.
- The findings showed that gata5 and gata6 work together to stabilize mesendoderm specification, highlighting the evolutionary connection of endoderm development in both echinoderms and vertebrates.
Hypoxia-inducible factor (HIF) 1α and HIF2α and the inhibitor of apoptosis survivin represent prominent markers of many human cancers. They are also widely expressed in various embryonic tissues, including the central nervous system; however, little is known about their functions in embryos. Here, we show that zebrafish HIF2α protects neural progenitor cells and neural differentiation processes by upregulating the survivin orthologues birc5a and birc5b during embryogenesis.
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- The genomic developmental program regulates gene expression through transcription factors and signaling pathways, with complex interactions determining cell specification and fate.
- Extensive studies on zebrafish have yielded substantial data about gene expression patterns, aiding in the reconstruction of gene regulatory networks (GRNs) involved in developmental processes like patterning and endoderm formation.
- The review outlines key regulatory motifs and feedback loops that influence dorsal-ventral polarity, and proposes a systematic approach to integrate GRNs in zebrafish while comparing them across different species for evolutionary insights.
The type V transforming growth factor-beta (TGF-beta) receptor (TbetaR-V) is hypothesized to be involved in cellular growth inhibition by TGF-beta(1). Recently, TbetaR-V was found to be identical to low density lipoprotein receptor-related protein-1 (LRP-1). Here we demonstrate that TGF-beta(1) inhibits growth of wild-type CHO cells but not LRP-1-deficient mutant cells (CHO-LRP-1(-) cells).
View Article and Find Full Text PDFThe type V TGF-beta receptor (TbetaR-V)/IGFBP-3 receptor mediates the IGF-independent growth inhibition induced by IGFBP-3. It also mediates the growth inhibitory response to TGF-beta1 in concert with other TGF-beta receptor types, and its loss may contribute to the malignant phenotype of human carcinoma cells. Here we demonstrate that TbetaR-V is identical to LRP-1/alpha2M receptor as shown by MALDI-TOF analysis of tryptic peptides of TbetaR-V purified from bovine liver.
View Article and Find Full Text PDFNew planar GaAs heterojunction bipolar phototransistors have been designed and demonstrated. The devices use a GaAs/Al(0.3)Ga(0.
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