Publications by authors named "WF Huang"
Purpose: Evidence concerning the effect of cardiovascular health (CVH) on the risk of metabolic dysfunctional-associated steatotic liver disease (MASLD) is scarce. This study aimed to investigate the association between CVH and MASLD.
Methods: 5680 adults aged ≥ 20 years from the National Health and Nutrition Examination Survey 2017-March 2020 were included.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide. The pan-immune-inflammation value (PIV) has been proposed as a biomarker for assessing immune status and inflammation. There is currently no evidence regarding the effect of PIV on the risk of MASLD.
View Article and Find Full Text PDFBerries are highly valued for their rich phenolic content, particularly anthocyanins, which are known for their antioxidative properties and potential effectiveness against depression. This study identified and quantified anthocyanin profiles in blueberry, blackberry, black mulberry, and cranberry using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS), followed by in vivo evaluation of their antidepressant-like activities. Blueberry and black mulberry showed significant levels of cyanidin-3-galactoside and cyanidin.
View Article and Find Full Text PDFBackground: In this study, using Taiwan's National Health Insurance (NHI) as an example of a single-payer system, we examined the extent of pharmaceutical procurement profits (PPP) and evaluated their impact on the financial performance of healthcare institutions.
Methods: We extracted data from financial statements and healthcare service declarations of NHI-contracted hospitals from 2015 to 2021. Financial data concerning PPP, health service profits (HSP), and total operating profits (TOP) from each hospital were analyzed.
Article Synopsis
- IgA vasculitis (IgAV) is a systemic small vessel inflammation predominantly affecting adults, often presenting with gastrointestinal symptoms prior to skin purpura, complicating early diagnosis.
- A retrospective study involving 108 adult patients from three hospitals in China focused on their abdominal imaging and endoscopic results to aid in identifying IgAV early.
- Key findings included a high prevalence of acute abdominal pain, bowel wall thickening on imaging, erosions during endoscopy, with the duodenum and ileum being the most affected areas, and notable laboratory abnormalities indicating inflammation.
Inflammatory bowel disease (IBD) is a chronic, debilitating condition with limited therapeutic options. Dietary components like blueberries have emerged as potential modulators of inflammation and tissue repair in gastrointestinal diseases. This study investigated endoplasmic reticulum (ER) stress-mediated apoptosis mediated protective effects of blueberries in ameliorating dextran sulfate sodium (DSS)-induced IBD.
View Article and Find Full Text PDFCranberry is abundantly rich in anthocyanins, a type of flavonoid with potent antioxidant properties and the resistance against certain diseases. In this study, anthocyanin-rich cranberry extract was extracted, purified, and its components were analyzed. 92.
View Article and Find Full Text PDFUnusual Endoscopic Findings of Mucosa-Associated Lymphoid Tissue Lymphoma.
Am J Gastroenterol
January 2025
Background And Aim: The incidence of rectal neuroendocrine tumors (R-NETs) has increased in recent years. However, the predictors of lymph node (LN) metastasis and clinical outcomes, particularly following endoscopic treatment, remain unclear. Our study aims to elucidate the potential risk factors for LN metastasis and the clinical outcomes of patients undergoing endoscopic resection in R-NETs.
View Article and Find Full Text PDFArticle Synopsis
- * In studies, synthetic QMP significantly reduced Nosema ceranae infection rates and slowed disease development, especially at lower doses, but these effects weakened at higher doses.
- * To ensure clear results, researchers should avoid using QMP in cage studies and explore various infectious doses with shorter incubation periods, while also noting that replacing a queen may help control Nosema infection as effectively as fumagillin treatment.
Background: The role of endoscopic resection (ER) in gastric gastrointestinal stromal tumors (GISTs) has not been fully elucidated.
Aims: The purpose of this work was to evaluate the clinical effectiveness and safety of ER in patients with GISTs originating from the muscularis propria (MP).
Methods: A total of 233 consecutive patients with gastric GISTs originating from the MP layer, who underwent ER between February 2012 and May 2023, were included in this study.
A core-shell nanostructure of gold nanoparticles@covalent organic framework (COF) loaded with palladium nanoparticles (AuNPs@COF-PdNPs) was designed for the rapid monitoring of catalytic reactions with surface-enhanced Raman spectroscopy (SERS). The nanostructure was prepared by coating the COF layer on AuNPs and then in situ synthesizing PdNPs within the COF shell. With the respective SERS activity and catalytic performance of the AuNP core and COF-PdNPs shell, the nanostructure can be directly used in the SERS study of the catalytic reaction processes.
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- - The study focused on children with unilateral cerebral palsy (UCP) and their challenges with handwriting, emphasizing the importance of visual-motor integration (VMI) and how conventional assessments may not accurately reflect their performance.
- - A new computer-aided measure of VMI (CAM-VMI) was developed to objectively assess VMI through geometric shapes and compare the performance of 28 children with UCP to typically-developing peers using both CAM-VMI and the Beery-VMI tests.
- - Results showed significant differences in VMI performance between the two groups, with the square shape emerging as a key predictor of VMI performance in children with UCP, highlighting its potential role in clinical evaluations.
Hydrogen sulfide (HS), an important gas signal molecule, participates in intercellular signal transmission and plays a considerable role in physiology and pathology. However, in-situ monitoring of HS level during the processes of material transport between cells remains considerably challenging. Herein, a cell membrane-targeted surface-enhanced Raman scattering (SERS) nanoprobe was designed to quantitatively detect HS secreted from living cells.
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- - Oxyntic gland neoplasm (OGN) is a rare type of gastric cancer, with a prevalence of 0.047% among the patients analyzed in a study involving 36 individuals from 2019 to 2023, most of whom were around 55 years old.
- - Most OGNs were small (≤10 mm), primarily found in the upper stomach, and showed distinctive features like slight elevation and dilated blood vessels.
- - Both endoscopic treatments (EMR-P and ESD) were effective and safe, with no complications reported, and EMR-P was found to be at least as effective as ESD, especially for smaller tumors, leading to favorable overall prognosis.
Background: Patients with hematological malignancies received multiple hypodermic injections of recombinant human granulocyte colony-stimulating factor. Procedural pain is one of the most common iatrogenic causes of pain in patients with hematological malignancies. It is also identified as the most commonly occurring problem in clinical care in the Department of Hematology and Oncology at Shenzhen University General Hospital.
View Article and Find Full Text PDF[Efficacy and Survival of Venetoclax Based Regimen in the Treatment of Acute Myeloid Leukemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2023
Article Synopsis
- - The study assessed the effectiveness of venetoclax-based regimens in treating acute myeloid leukemia (AML) through a retrospective analysis of 79 patients, focusing on their response rates and survival outcomes.
- - Among the patients, those with newly diagnosed unfit AML showed a higher complete remission/CR with incomplete hematologic recovery (CR/CRi) rate of 60.5%, compared to 27.8% in relapsed/refractory AML, with specific gene mutations offering significant benefits in the unfit cohort.
- - The median overall survival for all patients was 9.1 months, with unfit AML patients living significantly longer (14.1 months) than those with relapsed/refractory AML (
Article Synopsis
- The study investigates the effectiveness and safety of the CDCAG regimen (chidamide, decitabine, cytarabine, aclarubicin, and G-CSF) for treating relapsed/refractory acute myeloid leukemia (R/R AML).
- A total of 67 patients were analyzed, with 65 eligible for response and survival evaluation, revealing a 56.9% complete remission rate and a median overall survival (OS) of 9.6 months.
- Patients with specific gene mutations showed a higher overall response rate and better OS, suggesting potential benefits from this treatment in the context of allogeneic hematopoietic stem cell transplantation.