Exercise test in women and men aged 75-77 years.

The purpose of this study was to investigate the physiological response to an exercise test in 75- to 77-year-old women and men. Out of a systematically chosen and representative sample of 1,245 persons from a population at the age of 70, 649 individuals remained available at the age of 75-77 years. An exercise test was performed in 335 participants (52%), 174 women and 161 men.

Physical capacity and dyspnea in patients with asthma-like symptoms but negative asthma tests.

Ten female patients with asthma-like symptoms but negative asthma tests (study group) were compared with 10 female asthmatics in an exercise test with and without pretreatment with beta 2-stimulants. The aim was to determine whether the asthma-like symptoms in the patients of the study group could be explained by bronchoconstriction, circulatory abnormalities, or physical unfitness when provoked physically, and whether the exercise test could be used to distinguish these patients from asthmatics. Without pretreatment, the asthma group reacted with bronchoconstriction, as indicated by postexercise systematic changes in PEFR, FEV1, FVC, and SaO2, which were not seen in the study group.

Endurance training effect on individuals with postpoliomyelitis.

Objective: To determine the effects of an endurance training program on the exercise capacity and muscle structure and function in individuals with postpolio syndrome.

Design: Preexercise and postexercise testing was performed with muscle strength evaluations using isokinetic testing as well as hand-held Myometer. Muscle fatigue was determined by use of isokinetic testing, and endurance was determined by exercise testing.

Urinary excretion of histamine and methylhistamine in testicular feminizing syndrome.

Histamine is implicated in several reproductive functions. Correlation between histamine metabolism and sex hormones has been a matter of interest for many years. Urinary histamine excretion has been studied under various experimental conditions in different species.

Dyspnoea in chronic primary fibromyalgia.

We investigated the prevalence of dyspnoea, according to a 5-grade score proposed by the World Health Organization (WHO), among 87 consecutive women (age 44.0 +/- 8.4, range 26-65 years), with severe chronic primary fibromyalgia (CPF).

Myotonic dystrophy treated with selenium and vitamin E.

We have previously reported the successful treatment of a patient with myotonic dystrophy with selenium and vitamin E. This paper deals with the treatment of a further five patients with myotonic dystrophy in different stages. All five patients improved subjectively and objectively in two or more respects.

Effects of a training programme for elderly people on mineral content of the heel bone.

Physical inactivity can cause rapid bone loss. Different forms of physical activity are recommended for osteoporosis. The scientific background for such recommendations, however, is usually weak.

Effect of a training programme for pensioners on condition and muscular strength.

Physical training was performed by 22 women aged between 63 and 84 yr and 4 men aged between 74 and 86 yr twice a week for 10 mths. Some subjects had moderate disorders but all of them lived in their own homes. Apart from using body weight and elastic bands, no special equipment was used as resistance.

The effect of acute and chronic exercise on thyroid hormones in obesity.

Thyroid hormones were measured before, during and after acute exercise (60 min) or physical training (3 months) in obese women. Thyroid stimulating hormone concentration increased during acute work and decreased immediately after. No changes were seen during the two following days.

Studies on histamine metabolism in allergen-induced asthma.

The excretion of histamine (Hi) and it metabolite methyhistamine (MeHi) was determined in separated fractions of urine up to 12h after standardized allergen provocations in 18 adult patients with defined extrinsic bronchial asthma. The main histamine metabolite, methylimidazoleacetic acid (MeImAA), was measured in six of the patients. After positive provocations (decrease in FEV1 greater than 20%) the excretion of Hi was significantly increased during 3h and that of MeHi during 4h after challenge.

Intramedullary pressure of the patella in Chondromalacia.

Degenerative changes in load-bearing joints are often combined with altered intramedullary circulation. This may cause an alteration in intramedullary pressures. It has been said that articular symptoms are connected with a change in intramedullary pressures being high they are suspected to cause pain.

Studies on histamine metabolism in intrinsic bronchial asthma.

Histamine metabolism was investigated in patients with intrinsic asthma, during the acute phase and in remission, by determination of the urinary excretion of histamine metabolites. During acute attacks the excretion of methylhistamine (MeHi) and 1-methyl-4-imidazoleacetic acid (MeImAA) was significantly increased compared with healthy subjects. The excretion of MeHi was significantly increased during acute attacks compared with remission.

Effects of long-term physical training on body fat, metabolism, and blood pressure in obesity.

Twenty-seven women with varying degrees of obesity were physically trained for 6 mo on an ad lib. diet. Body fat changes were positively correlated with the number of fat cells in adipose tissue.

Histamine metabolism in normal pregnancy and in toxaemia of pregnancy.

The urinary excretion of histamine and its metabolites, methylhistamine, methylimidazoleacetic acid and imidazoleacetic acid, was measured under standardized dietary conditions in 24 women with normal pregnancies and in eleven patients with toxaemia of pregnancy. In addition, histamine metabolism was studied in five healthy women at delivery and in four other healthy pregnant women during treatment with aminoguanidine, which is an inhibitor of diamino oxidase (histaminase). A slight increase in the urinary excretion of methylimidazoleacetic acid was observed in normal pregnancy as well as in toxaemia of pregnancy compared to non-pregnant women.

Histamine metabolism and female sex hormones in women.

Oral combined contraceptives did not seem to alter histamine metabolism in females. During treatment with gonadotrophic hormones in four amenorrhoeic patients there was a tendency towards increasing excretion of methylhistamine (MeHi) followed by a sudden decrease corresponding to changes in the urinary estrogen. The excretion of methylimidazoleacetic acid (MeImAA) seemed to parallel that of MeHi.

Histamine metabolism during the menstrual cycle.

The urinary excretion of histamine and its metabolites methylhistamine (MeHi) and methylimidazoleacetic acid (MeImAA) was measured during the menstrual cycle in nine healthy women, one allergic woman and three non-pregnant women with anovulatory regular cycles. Simultaneous urinary analyses of luteinizing hormone (LH) and total estrogens were performed. The healthy women showed individual variations in the excretion of histamine, MeHi and MeImAA.

Effect of lumbar sympathetic blockade and chlorpromazine-induced adrenergic alpha-receptor blockade on skin temperature in peripheral arterial diseases.

The post-cooling toe temperature changes after lumbar sympathetic blockade and after intramuscular administration of an adrenergic alpha-receptor blocking substance (chlorpromazine) were studied in 14 patients with impending gangrene because of peripheral arterial insufficiency. The post-cooling temperature rise was similar after sympathetic blockage and chlorpromazine administration and significantly different from the basal toe temperature changes after cooling. It is concluded that administration of an adrenergic alpha-receptor blocking substance is as good as the lumbar sympathetic blockage for evaluation of a remaining sympathetic vasomotor tone in arterial disease patients.

Effects of female sex hormones on histamine metabolism in guinea-pigs.

Determination of the urinary excretion of histamine and methylhistamine was performed in intact and gonadectomized male and female guinea-pigs. The excretion of methylhistamine varied more than that of histamine both in the same animal and between different animals. The urinary excretion of histamine and methylhistamine reflects fairly well the total histamine turnover in the animal, provided that aminoguanidine is administered to inhibit diamine oxidase activity.

Histamine metabolism and gastric secretion in experimental burns in the rat.

The urinary excretion of histamine and the histamine formation in burned and control male and female rats were measured. With increasing temperature, the histamine excretion increased in male and female rats. The histamine formation was increased in burned skin.