Nf-Root: A Best-Practice Pipeline for Deep-Learning-Based Analysis of Apoplastic pH in Microscopy Images of Developmental Zones in Plant Root Tissue.

Hormonal mechanisms associated with cell elongation play a vital role in the development and growth of plants. Here, we report Nextflow-root (nf-root), a novel best-practice pipeline for deep-learning-based analysis of fluorescence microscopy images of plant root tissue from A. thaliana.

Phytochemical Characterization Utilizing HS-SPME/GC-MS: Exploration of the Antioxidant and Enzyme Inhibition Properties of Essential Oil from Saudi L.

This study aimed to analyze the chemical composition and biological activities of L. essential oil, focusing on its antioxidant and enzyme inhibition (α-amylase and urease) properties. Additionally, in vitro pharmacokinetic and pharmacodynamic evaluations were conducted through in silico molecular docking and BOILED-Egg models to assess its therapeutic potential and its potency in treating oxidative-stress-related diseases.

Exploring the therapeutic potential of Saudi (L.) DC. Essential oil: Insights into antioxidant, analgesic, and hepatorenal protective effects.

Lately, the herb's essential oils have received the intense attention of researchers and pharmaceutical agencies. The chemical composition, antioxidant, analgesic activity, anti-hyperpyrexia, and hepatorenal protective effects of the (L.) DC.

Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events.

A diagnosis of epilepsy has significant consequences for an individual but is often challenging in clinical practice. Novel biomarkers are thus greatly needed. Here, we investigated how common genetic factors (epilepsy polygenic risk scores, [PRSs]) influence epilepsy risk in detailed longitudinal electronic health records (EHRs) of > 700k Finns and Estonians.

A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.

Polygenic scores (PGSs) offer the ability to predict genetic risk for complex diseases across the life course; a key benefit over short-term prediction models. To produce risk estimates relevant to clinical and public health decision-making, it is important to account for varying effects due to age and sex. Here, we develop a novel framework to estimate country-, age-, and sex-specific estimates of cumulative incidence stratified by PGS for 18 high-burden diseases.

Impact of treated wastewater on plant growth: leaf fluorescence, reflectance, and biomass-based assessment.

The study evaluated the impact of treated wastewater on plant growth through the use of hyperspectral and fluorescence-based techniques coupled with classical biomass analyses, and assessed the potential of reusing treated wastewater for irrigation without fertilizer application. Cherry tomato () and cabbage ( L.) were irrigated with tap water (Tap), secondary effluent (SE), and membrane effluent (ME).

Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events.

A diagnosis of epilepsy has significant consequences for an individual but is often challenging in clinical practice. Novel biomarkers are thus greatly needed. Here, we investigated how common genetic factors (epilepsy polygenic risk scores, [PRSs]) influence epilepsy risk in detailed longitudinal electronic health records (EHRs) of > 360k Finns spanning up to 50 years of individuals' lifetimes.

Headspace Solid Phase Micro-Extraction of Volatile Constituents Produced from Saudi and Molecular Docking Study of Potential Antioxidant Activity.

L., commonly known as Shazab in Saudi Arabia, is one of the famous culinary plants belonging to the Rutaceae family. It is commonly used in ethnomedicine in treating numerous diseases.

Chemical Composition of Flowers Essential Oil and Hepato-Therapeutic Effect against Carbon Tetrachloride-Induced Toxicity (In-Vivo).

The liver is a crucial organ among body organs due to its wide functions, in particular, detoxification and metabolism. Exposure to detrimental chemicals or viral infections may provoke liver dysfunction and ultimately induce liver tissue damage. Finding natural substances for liver disease treatment to overcome the conventional treatments' side effects has attracted the attention of researchers worldwide.

Rating Spine Surgeons: Physician Review Websites Versus a Patient-reported Outcomes-derived Ranking.

Study Design: This was an observational study.

Objectives: This study aims to determine the correlation between patient-reported outcomes (PROs) pulled from a national spine registry and physician ratings from physician review websites (PRWs).

Summary Of Background Data: PRWs are frequently utilized by patients to make health care decisions; however, many PRWs appear to incorporate subjective experiences unrelated to a surgeon's clinical performance into ratings.

Monitoring COVID-19 spread in Prague local neighborhoods based on the presence of SARS-CoV-2 RNA in wastewater collected throughout the sewer network.

Many reports have documented that the presence of SARS-CoV-2 RNA in the influents of municipal wastewater treatment plants (WWTP) correlates with the actual epidemic situation in a given city. However, few data have been reported thus far on measurements upstream of WWTPs, i.e.

Headspace solid-phase microextraction method for extracting volatile constituents from the different parts of Saudi L. and their antimicrobial activity.

L. is a famous aromatic herb that is widely used as a spice and has been applied in folk medicine to cure many diseases. The current work was carried out to compare the chemical composition and antimicrobial potency of essential oils obtained from the different parts of Saudi .

A Patient-specific Approach to Alignment and Proximal Junctional Kyphosis Risk Assessment in Adult Spinal Deformity Surgery: Development and Validation of a Predictive Tool.

Study Design: This was a single-institution, retrospective cohort study.

Objective: We aimed to develop a predictive model for proximal junctional kyphosis (PJK) severity that considers multiple preoperative variables and modifiable surgical alignment.

Summary Of Background Data: PJK is a common complication following adult deformity surgery.

Team Approach: Spinopelvic Dissociation.

»: Spinopelvic dissociation is a complex and variable injury pattern that requires an integrated, multidisciplinary team including orthopaedic trauma and spine surgeons.

»: Protocols and efficient channels of communication should be in place at tertiary Level-I trauma centers to ensure appropriate and timely treatment of patients with spinopelvic dissociation.

»: Patients with spinopelvic dissociation may present with acute neurological deficits and impending cauda equina syndrome, necessitating urgent, coordinated care.

Commissioning of the new water line of the Central wastewater treatment plant in Prague and its impact on the operation of the existing water line.

This paper describes the commissioning of the new water line (NWL) of the Central wastewater treatment plant in Prague and also the gradual reduction of the existing water line (EWL) loading. Concerning the NWL, the gradual start-up of the process without inoculation will be described. As to the EWL, the presentation describes the adaptation of the EWL operation to the relatively quick reduction of loading to approximately 35%.

The development in biological wastewater treatment over the last 50 years.

The paper summarizes the development in the understanding and practical application of the activated sludge process over the last 50 years. Since its invention, the activated sludge process has been a big challenge to design engineers. Traditionally, the technology was covered by sanitary engineers.

Treated wastewater reuse for irrigation: Pros and cons.

The appropriateness of using treated wastewater for crop or agricultural irrigation remains a bone of contention among experts and policymakers. Here, we outline and analyze not only the benefits but also the drawbacks of such a practice in order to suggest a way forward. To ensure that our review reflects the state-of-the-art in terms of technological advances and best practices, only literature published in the last decade is considered except for literature on the history of reuse.

Clary Sage Essential Oil and Its Effect on Human Mood and Pulse Rate: An in vivo Pilot Study.

Clary sage () is a xerophytic biennial plant typical for the Mediterranean region. It is cultivated for its essential oil, which is widely used in the flavor and fragrance industry as well as in aromatherapy for its relaxing and immunomodulatory effect. In this pilot investigation, clary sage essential oil was analyzed by GC-MS as well as GC-FID and examined regarding its effects on pulse, blood pressure and mood in healthy human female and male subjects.

Anaphylaxis secondary to albumin infusion during posterior spinal fusion for pediatric scoliosis.

Study Design: Case report.

Objectives: To describe intraoperative administration of albumin as a cause of immunoglobulin E (IgE)-mediated anaphylaxis and cardiac arrest in an adolescent with adolescent idiopathic scoliosis.

Background: Albumin is considered the reference intraoperative colloidal solution, and is used commonly as a volume expander for treating hypovolemia.

Review of Thermophysical Property Data of Octadecane for Phase-Change Studies.

In this work we derive temperature-dependent functions for the most important material properties needed for phase change studies with octadecane. Over 80 references are reviewed in which at least one thermophysical property of octadecane is measured. The functions are valid ±40 K around the melting temperature and are surrounded by their confidence interval.

Trajectory of Improvement in Myelopathic Symptoms From 3 to 12 Months Following Surgery for Degenerative Cervical Myelopathy.

Background: Degenerative cervical myelopathy (DCM) is a progressive disease resulting from cervical cord compression. The modified Japanese Orthopaedic Association (mJOA) is commonly used to grade myelopathic symptoms, but its persistent postoperative improvement has not been previously explored.

Objective: To utilize the Quality Outcomes Database (QOD) to evaluate the trajectory of outcomes in those operatively treated for DCM.

Failed Extensor Tendon Repairs: Extensor Tenolysis and Reconstruction.

Extensor tendon injuries are common and require a complex treatment strategy to appropriately manage them, including initial repair, revision/reconstruction options, and postoperative protocols. Intrinsic and extrinsic components of the extensor mechanism contribute to a complex anatomic apparatus but also allow for numerous reconstructive options. Tenolysis, tendon grafting, and local tissue reconstruction are all options that can be used to treat complex extensor tendon injuries, but the type of repair is dependent on which of the eight extensor zones and accompanying structures are injured.

Implications of comorbid OCD on PTSD treatment: A case study.

Given the high degree of diagnostic overlap and limited empirical literature surrounding the comorbidity between posttraumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD), appropriately conceptualizing the relationship between the comorbid symptoms and their impact on the treatment process can be challenging. This is especially true when the symptoms of the two disorders become functionally connected, with each symptom set maintaining the other. This article details the case of a veteran with comorbid PTSD and OCD who sought intensive trauma-focused treatment within the U.

Surgery without a surrogate: the low prevalence of healthcare power of attorney documents among preoperative patients.

Background: There has been little published research regarding the implementation of healthcare power of attorney (HCPOA) documents prior to elective surgery.

Objectives: This study aims to determine the prevalence of HCPOA documents incorporated into the electronic medical records (EMR) of patients undergoing elective surgery at four healthcare institutions. A secondary aim is to examine for correlations between HCPOA document implementation and demographic and preoperative clinical predictors.