The Known and Unknown of Global Tick-Borne Viruses.

Ticks are crucial vectors for various pathogens associated with human and animal diseases, including viruses. Nevertheless, significant knowledge gaps prevail in our understanding of tick-borne viruses (TBVs). We here examined existing studies on TBVs, uncovering 870 documented virus species across 28 orders, 55 families, and 66 genera.

Combination Adjuvants Enhance Recombinant H5 Hemagglutinin Vaccine Protection Against High-Dose Viral Challenge in Chickens.

Background: Recombinant avian influenza subunit vaccines often require adjuvants to enhance immune responses. This study aims to evaluate the immune-enhancing potential of seven combination adjuvants in specific pathogen-free (SPF) chickens.

Methods: SPF chickens were vaccinated with combinations of ISA78VG and adjuvants, including Quil-A, CpG, and monophosphoryl lipid A (MPLA).

Post-Marketing Surveillance of Adverse Events for the Recombinant Zoster Vaccine Among the Population over 50 Years Old in Hangzhou, China.

Objectives: This study aimed to evaluate the safety profile of the recombinant zoster vaccine (RZV) after its marketing in China.

Methods: We present a descriptive analysis and safety signal assessment of adverse events following immunization (AEFI) associated with RZV between September 2020 and December 2023. The descriptive data collected includes demographic characteristics and the classification of characteristics of AEFI cases, while vaccine safety signal assessment was evaluated using the reporting odds ratio (ROR).

Advancements in Nanoparticle-Based Adjuvants for Enhanced Tuberculosis Vaccination: A Review.

Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, necessitating the development of more effective vaccines. Nanoparticle-based adjuvants represent a promising approach to enhancing tuberculosis vaccine efficacy. This review focuses on the advantages of nanoparticulate-loaded vaccines, emphasizing their ability to improve antigen delivery, safety, and immunogenicity.

Knowledge Graph-Based In-Context Learning for Advanced Fault Diagnosis in Sensor Networks.

This paper introduces a novel approach for enhancing fault diagnosis in industrial equipment systems through the application of sensor network-driven knowledge graph-based in-context learning (KG-ICL). By focusing on the critical role of sensor data in detecting and isolating faults, we construct a domain-specific knowledge graph (DSKG) that encapsulates expert knowledge relevant to industrial equipment. Utilizing a long-length entity similarity (LES) measure, we retrieve relevant information from the DSKG.

Exploring Technology Acceptance of Healthcare Devices: The Moderating Role of Device Type and Generation.

The increasing adoption of healthcare devices necessitates a deeper understanding of the factors that influence user acceptance in this rapidly evolving area. Therefore, this study examined the factors influencing the technology acceptance of healthcare devices, focusing on radar sensors and wearable devices. A total of 1158 valid responses were used to test hypotheses, mediation, and moderation effects using SmartPLS 4.

Drug Delivery Across the Blood-Brain Barrier: A New Strategy for the Treatment of Neurological Diseases.

The blood-brain barrier (BBB) serves as a highly selective barrier between the blood and the central nervous system (CNS), and its main function is to protect the brain from foreign substances. This physiological property plays a crucial role in maintaining CNS homeostasis, but at the same time greatly limits the delivery of drug molecules to the CNS, thus posing a major challenge for the treatment of neurological diseases. Given that the high incidence and low cure rate of neurological diseases have become a global public health problem, the development of effective BBB penetration technologies is important for enhancing the efficiency of CNS drug delivery, reducing systemic toxicity, and improving the therapeutic outcomes of neurological diseases.

C2H2 Zinc Finger Protein Family Analysis of Identified a Salt-Tolerance Regulator, .

is a representative aromatic species. Wild roses are known for their strong tolerance to highly salty environments, whereas cultivated varieties of roses exhibit lower salt stress tolerance, limiting their development and industrial expansion. Previous studies have shown that C2H2-type zinc finger proteins play a crucial role in plants' resistance to abiotic stresses.

Insights into the Genomic Background of Nine Common Chinese Medicinal Plants by Flow Cytometry and Genome Survey.

Medicinal plants have long played a crucial role in healthcare systems, but limited genomic information on these species has impeded the integration of modern biological technologies into medicinal plant research. In this study, we selected nine common medicinal plants, each belonging to a different plant family, including (Chloranthaceae), (Vitaceae), (Fabaceae), (Cucurbitaceae), (Polygonaceae), (Caryophyllaceae), (Rubiaceae), (Lamiaceae), and (Asteraceae), to estimate their genome sizes and conduct preliminary genomic surveys. The estimated genome sizes by flow cytometry were 3.

Testing the Validity of the Montgomery-Koyama-Smith Equation for Calculating the Total Petal Area per Flower Using Two Rosaceae Species.

The size of floral organs is closely related to the successful reproduction of plants, and corolla size is, to some extent, indicative of the size of floral organs. Petals are considered to be homologous to leaves, so we also attempted to estimate the area of a single petal using the method that is typically employed for estimating single leaf area (i.e.

Development and Validation of Kompetitive Allele-Specific Polymerase Chain Reaction Markers for Seed Protein Content in Soybean.

Seed protein content is a critical trait in soybean breeding, as it provides a primary source of high-quality protein for both human consumption and animal feed. This study aimed to enhance molecular marker-assisted selection for high-protein soybean varieties by developing Kompetitive Allele-Specific Polymerase Chain Reaction (KASP) markers targeted at loci associated with seed protein content. Nineteen markers with high genotyping efficacy were identified through screening.

Different Impacts of Long-Term Tillage and Manure on Yield and N Use Efficiency, Soil Fertility, and Fungal Community in Rainfed Wheat in Loess Plateau.

Conservation tillage and fertilization are widely adopted in agricultural systems to enhance soil fertility and influence fungal communities, thereby improving agroecosystems. However, the effects of no-tillage combined with manure on grain yield, nitrogen use efficiency (NUE), soil fertility, and rhizosphere fungal communities remain poorly understood, particularly in rainfed wheat fields on the Loess Plateau. A 15-year field experiment was conducted at the Niujiawa Experimental Farm of the Cotton Research Institute, Shanxi Agricultural University.

The Adsorption Process and Mechanism of Benzo[a]pyrene in Agricultural Soil Mediated by Microplastics.

The coexistence of microplastics and benzo[a]pyrene (BaP) in the environment, and their interactions within agricultural soils in particular, have garnered widespread attention. This study focused on the early-stage interactions between microplastics and BaP, aiming to uncover their initial adsorption mechanisms. Despite the significant environmental toxicity of both pollutants, research on their mutual interactions in soil is still limited.

Neurotransmitter Metabolic Disturbance in Methamphetamine Abusers: Focus on Tryptophan and Tyrosine Metabolic Pathways.

Methamphetamine (METH) abuse disrupts the homeostasis of neurotransmitter (NT) metabolism, contributing to a wide range of neurological and psychological disorders. However, the specific effects of METH on NT metabolism, particularly for the tryptophan (TRP) and tyrosine (TYR) metabolic pathways, remain poorly understood. In this study, serum samples from 78 METH abusers and 79 healthy controls were analyzed using Ultra-High-Performance Liquid Chromatography with Tandem Mass Spectrometry (UHPLC-MS/MS).

A Review on Remediation Technology and the Remediation Evaluation of Heavy Metal-Contaminated Soils.

With the rapid development of industry and agriculture, soil contamination has become a significant environmental issue, and the heavy metal contamination of soils is an important part of it. The main methods for the remediation of heavy metal-contaminated soils include physical methods, chemical methods, biological methods, and combined remediation methods have been proposed as research deepens. However, the standards and evaluation methods for the remediation of heavy metal-contaminated soils are still not well-established.

Cell-Cycle-Related and Expression Elevated Protein in Tumor Upregulates the Antioxidant Genes via Activation of NF-κB/Nrf2 in Acute Liver Injury.

Background And Aims: Cell-cycle-related and expression elevated protein in tumor (CREPT, also named RPRD1B) is highly expressed in tumors and functions to promote tumorigenesis. However, the role of CREPT in the pathophysiology of acute liver injury is limited. Here, we demonstrate that CREPT plays an essential role during acute liver injury.

The Characteristics, Sources, and Health Risks of Volatile Organic Compounds in an Industrial Area of Nanjing.

This study investigates the chemical complexity and toxicity of volatile organic compounds (VOCs) emitted from national petrochemical industrial parks and their effects on air quality in an industrial area of Nanjing, China. Field measurements were conducted from 1 December 2022, to 17 April 2023, focusing on VOC concentrations and speciations, diurnal variations, ozone formation potential (OFP), source identification, and associated health risks. The results revealed an average total VOC (TVOC) concentration of 15.

Kashin-Beck Disease: A Risk Factor for Sarcopenia and Its Interaction with Selenium.

Objectives: We aimed to explore the possible effects of Kashin-Beck disease (KBD) on the risk of sarcopenia and its possible interaction in the association between the risk of sarcopenia and element concentration.

Methods: This cross-sectional study was conducted among individuals 18-75 years old in Qamdo, a KBD-endemic area. All individuals received physical and radiological examinations before recruitment.

The Association of Dietary Polyamines with Mortality and the Risk of Cardiovascular Disease: A Prospective Study in UK Biobank.

Background: Polyamines, including spermidine (SPD), spermine (SPM) and putrescine (PUT), are essential for cellular physiology and various cellular processes. This study aimed to examine the associations of dietary polyamines intake and all-cause mortality and incident cardiovascular disease (CVD).

Methods: This prospective cohort study included 184,732 participants without CVD at baseline from the UK Biobank who had completed at least one dietary questionnaire.

Development of a TaqMan qPCR for the Simultaneous Detection of the TuMV and BBWV2 Viruses Responsible for the Viral Disease in .

(Miq.) Pax, a highly valued Chinese medicinal plant, is experiencing a notable decline in yield and quality due to viral diseases, particularly caused those by TuMV and BBWV2. Currently, the absence of a quantitative detection method for these viruses in impedes the accurate diagnosis.

Proline Improves Pullulan Biosynthesis Under High Sugar Stress Condition.

Pullulan is an extracellular polysaccharide produced via the fermentation of . However, high sugar concentrations and hyperosmotic stress limit pullulan biosynthesis during the fermentation process. Therefore, we investigated the effects of proline supplementation on .

E2 Ubiquitin-Conjugating Enzymes Regulates Dengue Virus-2 Replication in .

, a major vector of dengue virus (DENV), has a global distribution. Identifying the key components of the ubiquitin system of essential for the replication of viruses could help identify targets for developing broad-spectrum antiviral strategies. This study explores the interaction between E2 ubiquitin-conjugating enzymes (Ubc9) and DENV-2 proteins (NS1, NS5, and E) using cell culture and mosquito models.

The Association of Blood Eosinophils and Neutrophils Expressing Eosinophilic Surface Markers with the Severity and Outcome of COVID-19.

(1) Background: The implication of type 2 (T2) inflammatory response in COVID-19 remains controversial. This study aimed to evaluate the association of eosinophils, neutrophils expressing eosinophilic surface markers and T2 cytokines with the severity and outcome of COVID-19. (2) Methods: Patients who were admitted to hospital due to COVID-19 from 18 December 2022 to 31 January 2023 were enrolled.

Application of and on Lipid Metabolism, Anti-Inflammatory, and Fecal Microbiota in Cats.

Probiotics have been used in functional foods and dietary supplements, and in recent years, they have become more widely used in pets. In our previous experiment, L-27-2 and L-14-1 were isolated from cat feces and proved to have positive effects on lipid metabolism in mice. To further discuss their possible effects in cats, a total of 12 healthy cats (British Shorthair) were randomly divided into two groups.

FDA-Approved Hydrogel-Mediated In Situ Sonodynamic and Chemotherapeutic Therapy for Pancreatic Cancer.

Albumin-bound paclitaxel (nab-PTX) nanoparticles have been proven effective in treating advanced pancreatic cancer. However, the clinical application of nab-PTX nanoparticles is often associated with suboptimal outcomes and severe side effects due to its non-specific distribution and rapid clearance. This study aims to develop a novel nanoplatform that integrates sonodynamic therapy (SDT) and chemotherapy to enhance treatment efficacy and reduce systemic side effects.