DriverDetector: An R package providing multiple statistical methods for cancer driver genes detection and tools for downstream analysis.

Identifying driver genes in cancer is a difficult task because of the heterogeneity of cancer as well as the complex interactions among genes. As sequencing data become more readily available, there is a growing need for detecting cancer driver genes based on statistical and mathematical modeling methods. Currently, plenty of driver gene identification algorithms have been published, but they fail to achieve consistent results.

Secrets revealed by the skin: initial success of tislelizumab and targeted therapy in advanced renal cell carcinoma-a case report and literature review.

Background: In renal cell carcinoma (RCC), skin metastases (SMs) occur in only 3.3% of cases and are even rarer as an initial manifestation of the disease. Although combination therapy with immune checkpoint inhibitors (ICIs) and targeted agents is the current standard of care, access to these treatments may be limited in certain regions due to cost constraints.

Construction of a disulfidptosis-associated lncRNA signature to predict prognosis in bladder cancer.

Background: Bladder cancer (BCa) is the most common neoplasm of the urinary system, and its high rates of progression and recurrence contribute to a generally poor prognosis, especially in advanced cases. It is reported that disulfidptosis is closely related with tumor proliferation. We aimed to construct a disulfidptosis-associated long non-coding RNA (lncRNA) signature that can predict prognosis and immune microenvironment in BCa.

Aberrant functional connectivity between the retrosplenial cortex and hippocampal subregions in amnestic mild cognitive impairment and Alzheimer's disease.

The posterior cingulate cortex and hippocampus are the core regions involved in episodic memory, and they exhibit functional connectivity changes in the development and progression of Alzheimer's disease. Previous studies have demonstrated that the posterior cingulate cortex and hippocampus are both cytoarchitectonically heterogeneous regions. Specifically, the retrosplenial cortex, typically subsumed under the posterior cingulate cortex, is an area functionally and anatomically distinct from the posterior cingulate cortex, and the hippocampus is composed of several subregions that participate in multiple cognitive processes.

Development and performance validation of an affordable and portable high-resolution darkfield polarization-sensitive multispectral imaging microscope for the assessment of radiation dermatitis and fibrosis.

Radiation therapy (RT) is widely used for cancer treatment but is found with side effects of radiation dermatitis and fibrosis thereby calling for timely assessment. Nevertheless, current clinical assessment methods are found to be subjective, prone to bias, and accompanied by variability. There is, therefore, an unmet clinical need to explore a new assessment technique, ideally portable and affordable, making it accessible to less developed regions too.

Effectiveness of combined physical exercise and cognitive training in older adults with cognitive impairment: A systematic review and meta-analysis.

Falls among cognitively impaired older adults are a global concern. The aim of this study was to assess the efficacy of combining physical exercise and cognitive training to improve balance among older adults. A systematic search of databases, including Embase, Medline-OVID, CINAHL-EBSCOhost, and Central-Cochrane Library, was conducted from March 9 to April 6, 2023.

An all-in-one microfluidic cryopreservation system and protocols with gradually increasing CPA concentration.

In regular biosample cryopreservation operations, dropwise pipetting and continuous swirling are ordinarily needed to prevent cell damage ( sudden osmotic change, toxicity and dissolution heat) caused by the high-concentration cryoprotectant (CPA) addition process. The following CPA removal process after freezing and rewarming also requires multiple sample transfer processes and manual work. In order to optimize the cryopreservation process, especially for trace sample preservation, here we present a microfluidic approach integrating CPA addition, sample storage, CPA removal and sample resuspension processes on a 30 × 30 × 4 mm three-layer chip.

DBU-catalyzed annulation strategy for modular assembly of 2,3-difunctionalized dihydrobenzofurans.

An organocatalytic approach for the construction of 2,3-dihydrobenzofuran scaffold through a formal [4 + 1] annulation of 2-(2-nitrovinyl)phenols and α-bromoacetophenones in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed.

Results from patient-derived xenograft models support co-administration of allopurinol and 6-mercaptopurine to reduce hepatotoxicity and improve event-free survival in pediatric acute lymphoblastic leukemia.

Not available.

A Stable Zn(II) Metal-Organic Framework as Turn-On and Blue-Shift Fluorescence Sensor for Amino Acids and Dipicolinic Acid in Living Cells or Using Aerosol Jet Printing.

Amino acids and dipicolinic acid (DPA) are important biomarkers for identifying human health. Establishing rapid, accurate, sensitive, and simple assays is essential for disease prevention and early diagnosis. In this work, a novel Zn(II) metal-organic framework (MOF) with the formula {[Zn(μ-OH)(BTDI)(dpp)]·dpp·4HO·2DMF} (, where denotes Jiangxi University of Science and Technology, HBTDI = 5,5'-(benzo[][1,2,5]thiadiazole-4,7-diyl)diisophthalic acid; dpp = 1,3-di(4-pyridyl)propane) was successfully synthesized via a mixed-ligands strategy.

Dissociation-Precipitation Chemistry of Lithium Polysulfides and Its Correlation to Dynamic Evolution of Cathode-Electrolyte Interphase in Highly Solvating Electrolyte.

Lithium-sulfur (Li-S) batteries has been regarded as one of the most promising next-generation energy storage systems due to their high theoretical energy density. However, the practical application of Li-S batteries is still hindered by the unstable cathode-electrolyte interphase and the early passivation of charge product (LiS), leading to poor cycling stability and low S utilization. Herein, we propose an electrolyte engineering strategy using highly solvating hexamethylphosphoramide (HMPA) as a co-solvent to elucidate the dissociation-precipitation chemistry of lithium polysulfides (LiPSs).

Aberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder.

White-matter tracts play a pivotal role in transmitting sensory and motor information, facilitating interhemispheric communication and integrating different brain regions. Meanwhile, sensorimotor disturbance is a common symptom in patients with major depressive disorder (MDD). However, the role of aberrant sensorimotor white-matter system in MDD remains largely unknown.

3D Covalent Organic Framework Membrane with Interactive Ion Nanochannels for Hydroxide Conduction.

Crystalline porous materials, known for their ordered structures, hold promise for efficient hydroxide conductivity in alkaline fuel cells with limited ionic densities. However, the rigid cross-linking of porous materials precludes their processing into membranes, while composite membranes diminish materials' conductivity advantage due to the interrupted phases. Here, we report a self-standing three-dimensional covalent organic framework (3D COF) membrane with efficient OH-transport through its interconnected 3D ionic nanochannels.

Soft biocompatible polymer optical fiber tapers for implantable neural devices.

Optical fibers are between the most common implantable devices for delivering light in the nervous system for optogenetics and infrared neural stimulation applications. Tapered optical fibers, in particular, can offer homogeneous light delivery to a large volume and spatially resolved illumination compared to standard flat-cleaved fibers while being minimally invasive. However, the use of tapers for neural applications has up to now been limited to silica optical fibers, whose large Young's modulus can cause detrimental foreign body response in chronic settings.

High-security physical layer encryption scheme for dual-mode index modulation-aided OFDM in magnetic induction communication.

A high security physical layer encryption scheme for dual-mode orthogonal frequency division multiplexing with index modulation (DM-OFDM-IM) in magnetic induction communication is proposed. The scheme utilizes DM-OFDM-IM, where subcarriers within each subblock are divided into two groups, each modulated by distinct signal constellations. DM-OFDM-IM leverages the sequential information from the modulated constellation to transmit extra information, leading to a substantial enhancement in spectral efficiency.

Clustering fast optimization strategy for holographic video displays.

Computer-generated holography (CGH) is an advanced technology for three-dimensional (3D) displays. While the stochastic gradient descent (SGD) method is effective for holographic optimization, its application to holographic video displays is computationally expensive, as each frame requires separate optimization. To address this, we propose a novel, to the best of our knowledge, clustering optimization strategy to accelerate the SGD process for holographic video displays.

Collagen Nanofiber-Lignin Composite Sponges with Adjustable Hierarchical Pore Structure for Efficient Low-Frequency Sound Absorption.

Current sound-absorbing materials, reliant on nonrenewable resources, pose sustainability and disposal challenges. This study introduces a novel collagen-lignin sponge (CLS), a renewable biomass-based material that combines collagen's acoustic properties with lignin's structural benefits. CLSs demonstrate high porosity (>0.

Mediterranean diet and dementia: MRI marker evidence from meta-analysis.

Background: Dementia is a growing public health concern with limited effective treatments. Diet may be a modifiable factor that significantly impacts brain health. Mediterranean diet (MeDi) has been suggested to be associated with brain Magnetic Resonance Imaging (MRI) markers related to dementia, but the existing evidence is inconsistent.

Liver transplantation for homozygous familial hypercholesterolemia: a retrospective analysis from Chinese experience.

Background: Homozygous familial hypercholesterolaemia (HoFH) increases risk of premature cardiovascular events and cardiac death. In severe cases of HoFH, clinical signs and symptoms cannot be controlled well by non-surgical treatments, liver transplantation (LT) currently represents the viable option.

Method: To assess the clinical efficacy, prognosis, and optimal timing of LT for HoFH, a retrospective analysis was conducted on the preoperative, surgical conditions, and postoperative follow-up of children who received an LT for HoFH at the Beijing Friendship Hospital over the period from December 2014 to August 2022.

Combined detection of monocyte distribution width and procalcitonin for diagnosing and prognosing neonatal sepsis.

Background: To assess the value of combined Monocyte Distribution Width (MDW) and Procalcitonin (PCT) detection in diagnosing and predicting neonatal sepsis outcomes.

Methods: This retrospective study, conducted from January 2022 to December 2023.A retrospective analysis of 39 neonatal sepsis and 30 non-infectious systemic inflammatory response syndrome (SIRS) cases was conducted.

The expansion and loss of specific olfactory genes in relatives of parasitic lice, the stored-product psocids (Psocodea: Liposcelididae).

Background: Booklice, belonging to the genus Liposcelis (Psocodea: Liposcelididae), commonly known as psocids, infest a wide range of stored products and are implicated in the transmission of harmful microorganisms such as fungi and bacteria. The olfactory system is critical for insect feeding and reproduction. Elucidating the molecular mechanisms of the olfactory system in booklice is crucial for developing effective control strategies.

Efficacy and safety of olverembatinib as maintenance therapy after allogeneic hematopoietic cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia.

Experience using olverembatinib as maintenance therapy in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph ALL) after allogeneic hematopoietic cell transplantation (allo-HCT) is limited. We retrospectively collected data from 26 patients with Ph ALL who received only olverembatinib as maintenance therapy after allo-HCT. Olverembatinib was administered as prophylaxis in 18 patients (69.

Alcohol consumption and ambulatory blood pressure-lowering effect in male patients on clinic blood pressure-guided antihypertensive treatment.

In the present analysis, we investigated the association between alcohol consumption and ambulatory blood pressure (BP) control in male patients after 8 weeks of antihypertensive therapy with two dihydropyridine calcium channel blockers. The study participants were hypertensive (clinic systolic/diastolic BP of 140-179/90-109 mmHg and 24-hour ambulatory systolic/diastolic BP ≥ 130/80 mmHg) patients enrolled in a randomized controlled trial and treated with amlodipine 5-10 mg or nifedipine gastrointestinal therapeutic system (GITS) 30-60 mg once daily. Alcohol consumption was classified as non-drinkers and drinkers.