Publications by authors named "W. Queisser"
Article Synopsis
- Proteolysis-targeting chimeras (PROTACs) are innovative molecules designed to promote the degradation of specific proteins by leveraging the body's natural protein breakdown systems.
- This study introduces a method to create covalent ligands that target the Von Hippel-Lindau (VHL) protein, specifically binding to the HIF1α binding site.
- The successful integration of these ligands into bifunctional degraders allows for the targeted degradation of proteins like BRD4 and the androgen receptor, broadening the potential applications of PROTACs in therapy.
Inflammation and oxidative stress are known to be involved in the pathogenesis of chronic kidney disease in humans, and in chronic renal failure (CRF) in rats. The aim of this work was to study the role of inflammation and oxidative stress in adenine-induced CRF and the effect thereon of the purported nephroprotective agent gum arabic (GA). Rats were divided into four groups and treated for 4 weeks as follows: control, adenine in feed (0.
View Article and Find Full Text PDFChronic hyperaldosteronism has been associated with an increased cancer risk. We recently showed that aldosterone causes an increase in cell oxidants, DNA damage, and NF-κB activation. This study investigated the mechanisms underlying aldosterone-induced increase in cell oxidants in kidney tubule cells.
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