Publications by authors named "W-R Silva"

Article Synopsis
  • SARS-CoV-2, identified in 2019, has led to a global pandemic with serious health and economic impacts, prompting the need for effective treatments alongside vaccines.
  • Flavonoids, particularly luteolin, show promise as antiviral agents against SARS-CoV-2 and their efficacy can be enhanced when combined with zinc, magnesium, and vitamin C.
  • Research indicates that luteolin effectively inhibits the virus's 3CLpro protease, suggesting a potential therapeutic strategy for COVID-19 treatment through a novel combination of luteolin and essential nutrients.
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The impact of invasive species on biodiversity, food security and economy is increasingly noticeable in various regions of the globe as a consequence of climate change. Yet, there is limited research on how climate change affects the distribution of the invasive Asian citrus psyllid Kuwayama (Hemiptera:Liviidae) in Ghana. Using maxnet package to fit the Maxent model in R software, we answered the following questions; (i) what are the main drivers for distribution, (ii) what are the -specific habitat requirements and (iii) how well do the risk maps fit with what we know to be correctly based on the available evidence?.

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  • One in ten COVID-19 infections lead to long COVID, characterized by prolonged symptoms, but the underlying mechanisms remain unclear.
  • In a study of 657 individuals, certain inflammatory markers were linked to long COVID symptoms, revealing connections to cardiorespiratory issues, fatigue, anxiety, gastrointestinal problems, cognitive impairments, and potential nerve tissue repair disturbances.
  • Findings suggest that targeting specific inflammatory pathways could offer new therapeutic options for treating different subtypes of long COVID in future clinical trials.*
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The phloem-limited bacteria, "Candidatus Liberibacter asiaticus" and "Ca. L. americanus", are the causal pathogens responsible for Huanglongbing (HLB).

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  • The study investigates how protease activity in lymph nodes affects the degradation of vaccine antigens, impacting the immune response.* -
  • Antigen breakdown is faster in areas like the subcapsular sinus and paracortex but slower near follicular dendritic cells (FDCs), which are crucial for effective immune responses.* -
  • Targeting antigens to FDCs improves the formation of germinal centers that focus on intact antigens, leading to stronger antibody responses compared to traditional immunization methods.*
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The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama (Hemiptera: Liviidae), is an efficient vector of "Candidatus Liberibacter" species, the causative agents implicated in citrus greening or huanglongbing (HLB). HLB is the most devastating citrus disease and has killed millions of citrus trees worldwide. Classical biological control using Tamarixia radiata Waterston (Hymenoptera: Eulophidae) against ACP has been successful in some regions.

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Circulating tumor DNA (ctDNA) sequencing guides therapy decisions but has been studied mostly in small cohorts without sufficient follow-up to determine its influence on overall survival. We prospectively followed an international cohort of 1,127 patients with non-small-cell lung cancer and ctDNA-guided therapy. ctDNA detection was associated with shorter survival (hazard ratio (HR), 2.

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Article Synopsis
  • The study investigates the persistence of germinal centre B cells for over 6 months following HIV Env protein immunization in rhesus monkeys, showing a significant increase in B cells at week 10 compared to conventional methods.
  • Continuous somatic hypermutation of the B cells during the 29-week period indicates ongoing selection pressure, leading to a substantial boost in HIV-neutralizing antibodies after a single booster.
  • Findings suggest that a longer priming strategy can enhance immune memory, allowing B cells to better recognize challenging antigens, potentially improving vaccine efficacy for difficult targets.
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How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in vivo. Highly multimerized immunogens preferentially rapidly activated cognate B cells, with little affinity discrimination.

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Despite growing evidence regarding the benefits of resistance training in hypertension, the large and abrupt rise of systolic blood pressure (SBP) observed during resistance exercise execution has resulted in concern about its safety. However, the manipulation of the resistance training protocol (RTP) organization, maintaining the work to rest ratio equated between protocols (W:R-equated), may reduce the SBP increase. To compare cardiovascular responses during two W:R-equated RTPs (3 × 15:88 s vs.

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Since its commercial introduction three-quarters of a century ago, fluid catalytic cracking has been one of the most important conversion processes in the petroleum industry. In this process, porous composites composed of zeolite and clay crack the heavy fractions in crude oil into transportation fuel and petrochemical feedstocks. Yet, over time the catalytic activity of these composite particles decreases.

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The aims of the present study were to verify the contributions of the energy systems during repeated sprints with a short recovery time and the associations of the time- and power-performance of repeated sprints with energetic contributions and aerobic and anaerobic variables. 13 healthy men performed the running-based anaerobic sprint test (RAST) followed by an incremental protocol for lactate minimum intensity determination. During the RAST, the net energy system was estimated using the oxygen consumption and the blood lactate responses.

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Results are presented from a search for heavy, right-handed muon neutrinos, N(μ), and right-handed W(R) bosons, which arise in the left-right symmetric extensions of the standard model. The analysis is based on a 5.0  fb(-1) sample of proton-proton collisions at a center-of-mass energy of 7 TeV, collected by the CMS detector at the Large Hadron Collider.

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This Letter presents a search for tb resonances in 1.04 fb(-1) of LHC proton-proton collision data collected by the ATLAS detector at a center-of-mass energy of 7 TeV. Events with a lepton, missing transverse momentum, and two jets are selected and the invariant mass of the corresponding final state is reconstructed.

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This letter reports on a search for hypothetical heavy neutrinos, , and right-handed gauge bosons, , in events with high transverse momentum objects which include two reconstructed leptons and at least one hadronic jet. The results were obtained from data corresponding to an integrated luminosity of 2.1 fb collected in proton-proton collisions at [Formula: see text] with the ATLAS detector at the CERN Large Hadron Collider.

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The caatinga semi-arid ecosystem of northeastern Brazil is characterized by a dry, spiny and predominantly deciduous shrub/forest vegetation, and many species there are potential sources of renewable resources for the oleochemical industry. The present research determined the oil content and fatty acid profiles of seeds from eight caatinga species. Seed oils were extracted in a Soxhlet system, and their fatty acid content identified by GC-MS.

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The consecutive structural genes for the iron-sulfur flavoenzyme sulfide dehydrogenase, sudB and sudA, have been identified in the genome of Pyrococcus furiosus. The translated sequences encode a heterodimeric protein with an alpha-subunit, SudA, of 52598 Da and a beta-subunit, SudB, of 30686 Da. The alpha-subunit carries a FAD, a putative nucleotide binding site for NADPH, and a [2Fe-2S]2+,+ prosthetic group.

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