Polydopamine/Melamine Sponge-Derived Compressible Carbon Foam for High-Performance Supercapacitors.

Electrode materials with a deformation capability are vital to the development of flexible supercapacitors. However, the preparation of porous carbons with a deformability remains challenging. Herein, a compressible carbon foam has been successfully prepared using a polydopamine/melamine sponge (PDA/MS) as the precursor material.

Impacts of intestinal microbiota metabolite trimethylamine N-oxide on cardiovascular disease: a bibliometric analysis.

Background: Trimethylamine N-oxide (TMAO), a metabolite dependent on intestinal microbiota, is closely related to the emergence, progression, and prognosis of cardiovascular disease (CVD), and has received increasing attention in recent years.

Objective: The current research hotspots and future development trends in TMAO and CVD field are found through bibliometrics analysis, which provides reference for further study.

Methods: The bibliometrics tools VOSviewer and CiteSpace were used to analyze the publications from the Web of Science Core Collection (WOSCC) database.

Unraveling the conversion mechanism toward spinel sulfides as cathode materials for Mg-ion batteries.

Rechargeable Mg batteries are promising candidates for achieving considerable high-energy-density. Enhancing the energy density can be achieved by integrating metallic Mg anodes with conversion-type cathode materials, which are characterized by multi-electron transfer process and elevated specific capacities in contrast to intercalation-type materials. Despite these advantages, the conversion-type cathodes still have some challenges of substantial volume expansion, sluggish diffusion kinetics and intricate mesophase evolution during repeated electrochemical reactions.

Interfacial oxygen bridges engineering between NbO and graphene towards advanced sodium ion capacitors.

NbO has become a focus of research for its suitability as an anode material in sodium ion capacitors (SICs), due to its open ionic channels. The integration of NbO with reduced graphene oxide (rGO) is known to boost its electrical conductivity. However, the sluggish interfacial charge transfer kinetics and interface collapse of NbO/rGO pose challenges to its rate capability and durability.

Realizing an Energy-Dense Potassium Metal Battery at -40 °C via an Integrated Anode-Free and Dual-Ion Strategy.

Potassium (K)-based batteries hold great promise for cryogenic applications owing to the small Stokes radius and weak Lewis acidity of K. Nevertheless, energy-dense (>200 W h kg) K batteries under subzero conditions have seldom been reported. Here, an over 400 W h kg K battery is realized at -40 °C via an anode-free and dual-ion strategy, surpassing these state-of-the-art K batteries and even most Li/Na batteries at low temperatures (LTs).

A phase I, randomized, placebo-controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults.

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection (LRTI) in infants worldwide. Nirsevimab, an extended half-life monoclonal antibody against RSV, is approved in China for the prevention of RSV lower respiratory tract disease in infants; however, global nirsevimab trials did not enroll Chinese infants. To inform the investigation of nirsevimab for the prevention of RSV LRTI in Chinese infants, this Phase I, randomized, placebo-controlled trial evaluated the pharmacokinetics (PK) and safety of nirsevimab in healthy Chinese adults.

High-Voltage Fe-Based Tunnel-Type Na[MnFeTiSn]O Cathode for Aqueous Rechargeable Sodium-Ion Battery.

Tunnel-type-structure NaMnO has been extensively researched for cathode material in aqueous rechargeable sodium-ion battery owing to its high specific capacity (120 mA h g), large channels facilitating Na extraction/insertion, chemical and electrochemical stability in aqueous electrolytes, and low cost. However, the low average working potential (0.1 V versus standard hydrogen electrode, SHE) and no more than half of its available theoretical capacity within full batteries limit the practical application.

Tendon Groove Technique: A Double-Bundle Footprint Technique for Anterior Cruciate Ligament Reconstruction.

Double-bundle (DB) anterior cruciate ligament (ACL) reconstruction has biomechanical advantages over single-bundle reconstruction. However, most studies perform the DB reconstruction with 2 femoral tunnels, which fails to provide an entire femoral footprint for ACL reconstruction. In this study, we describe a femoral double-bundle footprint technique for ACL reconstruction, named the tendon groove technique.

Single-Bundle Posterior Cruciate Ligament Reconstruction With Suture Tape Augmentation and Transtibial Tubercle Fixation.

The posterior cruciate ligament (PCL) is the strongest ligament of the knee and plays an important role in stabilizing the knee joint posteriorly. PCL tears are common injuries in sports injuries and traffic accidents; however, clinical outcomes after PCL reconstruction have not yet met clinicians' expectations, with a high postsurgery failure rate reported. Suture tape augmentation and supplementary fixation have shown ideal biomechanical properties in early studies.

Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension.

Background: Pulmonary hypertension (PH) is associated with endothelial dysfunction. However, the cause of endothelial dysfunction and its impact on PH remain incompletely understood. We aimed to investigate whether the hypoxia-inducible FUNDC1 (FUN14 domain-containing 1)-dependent mitophagy pathway underlies PH pathogenesis and progression.

Self-healing Micro-Supercapacitor Based on Robust Liquid Metal-CNT-PEDOT:PSS Film for Wireless Powering of Integrated Strain Sensor.

The limited energy density of micro-supercapacitors (MSCs) and challenges in their integration significantly impede the advancement of MSCs in wearable electronic devices. Here, this work designs a robust and wrinkled liquid metal-CNT-PEDOT:PSS film with high capacity and self-healing properties (defined as LM-CNT-PEDOT:PSS). The wrinkled structure further enhances tensile properties of LM-CNT-PEDOT:PSS and increases its active specific surface area per unit.

In vivo affinity maturation of the CD4 domains of an HIV-1-entry inhibitor.

Human proteins repurposed as biologics for clinical use have been engineered through in vitro techniques that improve the affinity of the biologics for their ligands. However, the techniques do not select against properties, such as protease sensitivity or self-reactivity, that impair the biologics' clinical efficacy. Here we show that the B-cell receptors of primary murine B cells can be engineered to affinity mature in vivo the human CD4 domains of the HIV-1-entry inhibitor CD4 immunoadhesin (CD4-Ig).

Endo-IP and lyso-IP toolkit for endolysosomal profiling of human-induced neurons.

Plasma membrane protein degradation and recycling are regulated by the endolysosomal system, wherein endocytic vesicles bud from the plasma membrane into the cytoplasm and mature into endosomes and then degradative lysosomes. As such, the endolysosomal system plays a critical role in determining the abundance of proteins on the cell surface and influencing cellular identity and function. Highly polarized cells, like neurons, rely on the endolysosomal system for axonal and dendritic specialization and synaptic compartmentalization.

A core-shell structured design for enhanced supercapacitor performance: coating Ni(OH)/Fe(OH) over NiMoO nanofibers.

This paper presents the development of a high-performance hydroxide-based supercapacitor electrode material, achieved through an innovative preparation strategy that integrates one-dimensional NiMoO nanofibers with Ni(OH)/Fe(OH) nanostructures, forming a NiMoO@Ni(OH)/Fe(OH) composite electrode. This material boasts a high specific capacitance (1753 F g at 1 A g) along with exceptional rate capability. The performance enhancement stems from synergies: Ni(OH)/Fe(OH)'s high surface area boosts charge storage and NiMoO nanofibers stabilize the structure, preventing nanosheet agglomeration and preserving open spaces for ion diffusion.

Highly flexible hybrid devices enabled by Ag-decorated ZnCoO electrodes.

Electrode materials with excellent performance are the basis for designing supercapacitors with outstanding stability and high specific capacitance. In this work, we prepared a type of ZnCoO nanosheet structure with Ag nanoparticles through a multi-step hydrothermal strategy. The as-fabricated composite presented a specific capacity of 2540 F g at 1 A g due to the synergetic effect of its components and structure.

Trials and tribulations of cell therapy for heart failure: an update on ongoing trials.

Heart failure (HF) remains a leading cause of mortality, responsible for 13% of all deaths worldwide. The prognosis for patients with HF is poor, with only a 50% survival rate within 5 years. A major challenge of ischaemia-driven HF is the loss of cardiomyocytes, compounded by the minimal regenerative capacity of the adult heart.

A composite of pineapple leaf-derived porous carbon integrated with ZnCo-MOF for high-performance supercapacitors.

Electrochemical energy storage heavily depends on the activity and stability of electrode materials. However, the direct use of metal-organic frameworks (MOFs) as supercapacitor electrode materials poses challenges due to their low electrical conductivity. In this study, pineapple leaf-derived biochar (PLB) was employed as a carrier for bimetallic ZnCo-MOF, resulting in the composite ZnCo-MOF@PLB-800, synthesized through growth and pyrolysis at 800 °C.

Triple-shelled Ni@MnO/C hollow spheres with enhanced performance for rechargeable zinc-ion capacitors.

Electrochemical activation techniques and the use of multi-shell structured materials are effective strategies to enhance the electrochemical performance of rechargeable aqueous zinc-ion capacitors (ZICs). In this study, we successfully synthesized spherical NiMn-MOFs a solvothermal method and used them as templates to prepare Ni/MnO@C nanospheres with different core-shell structures by adjusting the heating rate under an Ar atmosphere. The multi-shelled structure provides more active sites and alleviates structural strain associated with repeated Zn insertion/extraction processes.

Hybrid Particle Size Template Method for Controllable Synthesis of Nitrogen-Doped Multilevel Porous Carbon as High-Rate Zn-Ion Hybrid Supercapacitor Cathode Materials.

Achieving high rate performance without compromising energy density has always been a critical objective for zinc-ion hybrid supercapacitors (ZHSCs). The pore structure and surface properties of carbon cathode materials play a crucial role. We propose utilizing a hybrid particle size (20 and 40 nm) magnesium oxide templates to regulate the pore structure of nitrogen-doped porous carbon derived from the soybean isolate.

A Multimodal Deep Learning Nomogram for the Identification of Clinically Significant Prostate Cancer in Patients with Gray-Zone PSA Levels: Comparison with Clinical and Radiomics Models.

Rationale And Objectives: To establish a multimodal deep learning nomogram for predicting clinically significant prostate cancer in patients with gray-zone PSA levels.

Methods: This retrospective study enrolled 303 patients with pathological results between January 2018 and December 2022. Clinical variables and the PI-RADS v2.

Tunable Zn de-solvation behavior in MnO cathodes self-assembled phytic acid monolayers for stable aqueous Zn-ion batteries.

Sluggish ion diffusion kinetics at the electrode/electrolyte interface leads to insufficient rate capability and poor structural reversibility, which are mainly attributed to the hydrated Zn migration process being inhibited due to its huge de-solvation energy barriers. Herein, a self-assembly method is proposed in which a multifunctional monolayer with phytic acid (PA) is coated on the surface of MnO strongly attaching to the substrate with the formation of chemical bonding to effectively prevent the dissolution of PA in the electrolyte. Due to the negative charge and inherent ultra-hydrophilicity of PA, modified MnO demonstrates stronger adsorption of positive ions and captures reactive water molecules, easily accelerating the de-solvation process of interfacial hydrated Zn, efficiently achieving reversible Zn insertion/extraction.