MgCo(OH)@C as an electrode for supercapacitors: effect of doping level on energy storage capability.

Incorporating non-electrochemically active elements (such as Zn and Mg) into the framework of active components can enhance structural stability, leading to improved cycling performance. However, limited research has been conducted on the impact of varying doping concentrations. In this study, we conducted a comprehensive analysis of how different levels of Mg doping in Co(OH) affect the supercapacitor performance.

Prevention of Stroke in Intracerebral Haemorrhage Survivors with Atrial Fibrillation: Rationale and Design for PRESTIGE-AF Trial.

Adequate secondary prevention in survivors of intracerebral hemorrhage (ICH) who also have atrial fibrillation (AF) is a long-standing clinical dilemma because these patients are at increased risk of recurrent ICH as well as of ischemic stroke. The efficacy and safety of oral anticoagulation, the standard preventive medication for ischemic stroke patients with AF, in ICH patients with AF are uncertain. PRESTIGE-AF is an international, phase 3b, multi-center, randomized, open, blinded end-point assessment (PROBE) clinical trial that compared the efficacy and safety of direct oral anticoagulants (DOACs) with no DOAC (either no antithrombotic treatment or any antiplatelet drug).

High-Voltage Fe-Based Tunnel-Type Na[MnFeTiSn]O Cathode for Aqueous Rechargeable Sodium-Ion Battery.

Tunnel-type-structure NaMnO has been extensively researched for cathode material in aqueous rechargeable sodium-ion battery owing to its high specific capacity (120 mA h g), large channels facilitating Na extraction/insertion, chemical and electrochemical stability in aqueous electrolytes, and low cost. However, the low average working potential (0.1 V versus standard hydrogen electrode, SHE) and no more than half of its available theoretical capacity within full batteries limit the practical application.

Tendon Groove Technique: A Double-Bundle Footprint Technique for Anterior Cruciate Ligament Reconstruction.

Double-bundle (DB) anterior cruciate ligament (ACL) reconstruction has biomechanical advantages over single-bundle reconstruction. However, most studies perform the DB reconstruction with 2 femoral tunnels, which fails to provide an entire femoral footprint for ACL reconstruction. In this study, we describe a femoral double-bundle footprint technique for ACL reconstruction, named the tendon groove technique.

Single-Bundle Posterior Cruciate Ligament Reconstruction With Suture Tape Augmentation and Transtibial Tubercle Fixation.

The posterior cruciate ligament (PCL) is the strongest ligament of the knee and plays an important role in stabilizing the knee joint posteriorly. PCL tears are common injuries in sports injuries and traffic accidents; however, clinical outcomes after PCL reconstruction have not yet met clinicians' expectations, with a high postsurgery failure rate reported. Suture tape augmentation and supplementary fixation have shown ideal biomechanical properties in early studies.

Minipatellar Tunnels for Transosseous Fixation of Medial Patellofemoral Ligament Graft Using High-strength Suture.

Patellar dislocation is a common knee injury, with concomitant pathoanatomical risk factors that synergistically interact and predispose to patellofemoral instability. Medial patellofemoral ligament (MPFL) reconstruction has demonstrated significant potential in the re-establishment of MPFL anatomic and biological function, with low patellar redislocation rates. Although many techniques for MPFL reconstruction have been developed, challenges such as patella fractures and high costs persist.

Femtosecond Laser Introduced Cantilever Beam on Optical Fiber for Vibration Sensing.

An all-fiber vibration sensor based on the Fabry-Perot interferometer (FPI) is proposed and experimentally evaluated in this study. The sensor is fabricated by introducing a Fabry-Perot cavity to the single-mode fiber using femtosecond laser ablation. The cavity and the tail act together as a cantilever beam, which can be used as a vibration receiver.

Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension.

Background: Pulmonary hypertension (PH) is associated with endothelial dysfunction. However, the cause of endothelial dysfunction and its impact on PH remain incompletely understood. We aimed to investigate whether the hypoxia-inducible FUNDC1 (FUN14 domain-containing 1)-dependent mitophagy pathway underlies PH pathogenesis and progression.

Self-healing Micro-Supercapacitor Based on Robust Liquid Metal-CNT-PEDOT:PSS Film for Wireless Powering of Integrated Strain Sensor.

The limited energy density of micro-supercapacitors (MSCs) and challenges in their integration significantly impede the advancement of MSCs in wearable electronic devices. Here, this work designs a robust and wrinkled liquid metal-CNT-PEDOT:PSS film with high capacity and self-healing properties (defined as LM-CNT-PEDOT:PSS). The wrinkled structure further enhances tensile properties of LM-CNT-PEDOT:PSS and increases its active specific surface area per unit.

Clinical Characteristics and Survival Outcomes of Patients With Primary and Secondary Plasma Cell Leukemia According to the 2021 Definition: A Single Center Retrospective Study.

Introduction: Plasma cell leukemia (PCL) is a rare malignancy with poor overall survival (OS). Recently, its diagnostic criteria were revised by lowering the threshold of circulating plasma cells from ≥ 20% to ≥ 5%.

Methods: Between 2010 and 2024, patients with primary PCL (pPCL) and secondary PCL (sPCL) were identified at a tertiary center.

Fabrication of oxygen-vacancy abundant NiAl-layered double hydroxides for ultrahigh capacity supercapacitors.

The manipulation of oxygen vacancies is regarded as a viable approach to enhance the electrochemical properties of electrode materials. Herein, NiAl-LDH nanosheets with rich oxygen vacancies were successfully synthesized on the surface of nickel foam a conventional hydrothermal and chemical reduction strategy. The oxygen vacancies were introduced and modulated NaBH treatment, significantly enhancing the electrochemical properties.

Hollow Porous CoSe/ZnSe@MXene Anode with Multilevel Built-in Electric Fields for High-Performance Sodium Ion Capacitors.

Sodium ion capacitors (SICs) are promising candidates in energy storage for their remarkable power and energy density. However, the inherent disparity in dynamic behavior between the sluggish battery-type anodes and the rapid capacitor-type cathodes constrained their performance. To address this, we fabricated a hollow porous CoSe/ZnSe@MXene anode featuring multiheterostructure, utilizing facile etching and electrostatic self-assembly strategies.

Distributed direct air capture of carbon dioxide by synergistic water harvesting.

Adsorption-based direct air capture (DAC) of carbon dioxide, using chemisorbents like solid amines, has been widely recognized as a sustainable measure to contain atmospheric CO concentrations. However, the productivity and economic viability of DAC have been compromised by the high energy consumption for regenerating the adsorbents. Here, we show that by synergistically harvesting water and carbon dioxide from the atmosphere, we can regenerate the unit using in situ vapor purge at low energy and capital cost.

Triple-shelled Ni@MnO/C hollow spheres with enhanced performance for rechargeable zinc-ion capacitors.

Electrochemical activation techniques and the use of multi-shell structured materials are effective strategies to enhance the electrochemical performance of rechargeable aqueous zinc-ion capacitors (ZICs). In this study, we successfully synthesized spherical NiMn-MOFs a solvothermal method and used them as templates to prepare Ni/MnO@C nanospheres with different core-shell structures by adjusting the heating rate under an Ar atmosphere. The multi-shelled structure provides more active sites and alleviates structural strain associated with repeated Zn insertion/extraction processes.

Hybrid Particle Size Template Method for Controllable Synthesis of Nitrogen-Doped Multilevel Porous Carbon as High-Rate Zn-Ion Hybrid Supercapacitor Cathode Materials.

Achieving high rate performance without compromising energy density has always been a critical objective for zinc-ion hybrid supercapacitors (ZHSCs). The pore structure and surface properties of carbon cathode materials play a crucial role. We propose utilizing a hybrid particle size (20 and 40 nm) magnesium oxide templates to regulate the pore structure of nitrogen-doped porous carbon derived from the soybean isolate.

Hierarchical carbon nanofiber-based hybrid film on lightweight magnesium foil for ultrahigh energy density supercapacitors.

A novel hierarchical CNFs/NiP-Ni hybrid film has been successfully deposited on magnesium. Taking advantage of its super lightweight current collector and combinatorial battery-like/capacitor energy storage mechanisms, the constructed symmetric SC delivers a superior energy density (52.1 W h kg) with exceptional cycling stability (remaining 94% after 10 000 cycles).

Prophylactic use of probiotics as an adjunctive treatment for ischemic stroke via the gut-spleen-brain axis.

A growing body of research has focused on the role of spleen in orchestrating brain injury through the peripheral immune system following stroke, highlighting the brain-spleen axis as a potential target for mitigating neuronal damage during stroke. The gut microbiota plays a pivotal role in the bidirectional communication between the gut and the brain. Several studies have suggested that probiotic supplements hold promise as a strategic approach to maintaining a balanced intestinal microecology, reducing the apoptosis of intestinal epithelial cells, protecting the intestinal mucosal and blood-brain barrier (BBB), enhancing both intestinal and systemic immune functions, and thereby potentially affecting the pathogenesis and progression of ischemic stroke.

Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader.

Selective degradation of cyclin-dependent kinases 12 and 13 (CDK12/13) emerges as a new potential therapeutic approach for triple-negative breast cancer (TNBC) and other human cancers. While several proteolysis-targeting chimera (PROTAC) degraders of CDK12/13 were reported, none are orally bioavailable. Here, we report the discovery of as a potent, selective, and orally bioavailable CDK12/13 PROTAC degrader.

Vaccine Potency and Structure of Yeast-Produced Polio Type 2 Stabilized Virus-like Particles.

Poliovirus (PV) is on the brink of eradication due to global vaccination programs utilizing live-attenuated oral and inactivated polio vaccines. Recombinant PV virus-like particles (VLPs) are emerging as a safe next-generation vaccine candidate for the impending polio-free era. In this study, we investigate the production, antigenicity, thermostability, immunogenicity, and structures of VLPs derived from PV serotype 2 (PV2) wildtype strain and thermally stabilized mutant (wtVLP and sVLP, respectively).

Controllable construction of a 3D-honeycomb-like porous carbon network as a high-performance cathode for promoting Zn-ion storage capability.

Inheriting the energy storage mechanism of supercapacitors and rechargeable ion batteries, zinc ion capacitors (ZICs) greatly increase their energy density at high power without sacrificing their life span. However, sluggish kinetics and insufficient active sites for Zn storage induced by the significant mismatch of charge carriers with limited pore size hinder the efficient Zn storage and smooth application of carbonaceous cathode materials. Herein, a three-dimensional honeycomb-like porous carbon network (HPCN) was fabricated, which can reduce the diffusion barrier for fast kinetics, produce a high-density defect area, effectively increase active sites for charge storage, and generate a high nitrogen-doping content.

Ultrathin 2D-2D MXene-LDH Interlayer with High Polysulfide Adsorption Ability for Advanced Li-S Batteries.

Lithium-sulfur (Li-S) batteries are considered as promising energy storage systems due to the high energy density of 2600 W h kg. However, the practical application of Li-S batteries is hindered by the inadequate conductivity of sulfur and LiS, as well as the shuttle effect caused by polysulfides during the charge-discharge process. Introducing a conductive interlayer between the cathode and the separator to physically resist polysulfides represents an effective and straightforward approach to mitigate the shuttle effect in Li-S batteries.