High-Voltage Fe-Based Tunnel-Type Na[MnFeTiSn]O Cathode for Aqueous Rechargeable Sodium-Ion Battery.

Tunnel-type-structure NaMnO has been extensively researched for cathode material in aqueous rechargeable sodium-ion battery owing to its high specific capacity (120 mA h g), large channels facilitating Na extraction/insertion, chemical and electrochemical stability in aqueous electrolytes, and low cost. However, the low average working potential (0.1 V versus standard hydrogen electrode, SHE) and no more than half of its available theoretical capacity within full batteries limit the practical application.

Single-Bundle Posterior Cruciate Ligament Reconstruction With Suture Tape Augmentation and Transtibial Tubercle Fixation.

The posterior cruciate ligament (PCL) is the strongest ligament of the knee and plays an important role in stabilizing the knee joint posteriorly. PCL tears are common injuries in sports injuries and traffic accidents; however, clinical outcomes after PCL reconstruction have not yet met clinicians' expectations, with a high postsurgery failure rate reported. Suture tape augmentation and supplementary fixation have shown ideal biomechanical properties in early studies.

Harmonizing Wide Voltage Window and High Energy Density toward Asymmetric All-Solid-State Supercapacitor.

All-solid-state supercapacitors are known for their safety, stability, and excellent cycling performance. However, their limited voltage window results in lower energy density, restricting their widespread application in practical scenarios. Therefore, in this work, CC/MoO@TiCT negative electrode and MoAl-MnO/CC positive electrode materials are synthesized and prepared by electrochemical deposition co-coating and one-step hydrothermal methods, respectively, and assembled into an asymmetric supercapacitor (ASC) device based on the two electrode materials.

Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension.

Background: Pulmonary hypertension (PH) is associated with endothelial dysfunction. However, the cause of endothelial dysfunction and its impact on PH remain incompletely understood. We aimed to investigate whether the hypoxia-inducible FUNDC1 (FUN14 domain-containing 1)-dependent mitophagy pathway underlies PH pathogenesis and progression.

A composite of pineapple leaf-derived porous carbon integrated with ZnCo-MOF for high-performance supercapacitors.

Electrochemical energy storage heavily depends on the activity and stability of electrode materials. However, the direct use of metal-organic frameworks (MOFs) as supercapacitor electrode materials poses challenges due to their low electrical conductivity. In this study, pineapple leaf-derived biochar (PLB) was employed as a carrier for bimetallic ZnCo-MOF, resulting in the composite ZnCo-MOF@PLB-800, synthesized through growth and pyrolysis at 800 °C.

Highly Solvating Electrolytes with Core-Shell Solvation Structure for Lean-Electrolyte Lithium-Sulfur Batteries.

The practical energy density of lithium-sulfur batteries is limited by the low sulfur utilization at lean electrolyte conditions. The highly solvating electrolytes (HSEs) promise to address the issue at harsh conditions, but the conflicting challenges of long-term stability of radical-mediated sulfur redox reactions (SRR) and the poor stability with lithium metal anode (LMA) have dimmed the efforts. We now present a unique core-shell solvation structured HSE formulated with classical ether-based solvents and phosphoramide co-solvent.

Triple-shelled Ni@MnO/C hollow spheres with enhanced performance for rechargeable zinc-ion capacitors.

Electrochemical activation techniques and the use of multi-shell structured materials are effective strategies to enhance the electrochemical performance of rechargeable aqueous zinc-ion capacitors (ZICs). In this study, we successfully synthesized spherical NiMn-MOFs a solvothermal method and used them as templates to prepare Ni/MnO@C nanospheres with different core-shell structures by adjusting the heating rate under an Ar atmosphere. The multi-shelled structure provides more active sites and alleviates structural strain associated with repeated Zn insertion/extraction processes.

Hybrid Particle Size Template Method for Controllable Synthesis of Nitrogen-Doped Multilevel Porous Carbon as High-Rate Zn-Ion Hybrid Supercapacitor Cathode Materials.

Achieving high rate performance without compromising energy density has always been a critical objective for zinc-ion hybrid supercapacitors (ZHSCs). The pore structure and surface properties of carbon cathode materials play a crucial role. We propose utilizing a hybrid particle size (20 and 40 nm) magnesium oxide templates to regulate the pore structure of nitrogen-doped porous carbon derived from the soybean isolate.

A Multimodal Deep Learning Nomogram for the Identification of Clinically Significant Prostate Cancer in Patients with Gray-Zone PSA Levels: Comparison with Clinical and Radiomics Models.

Rationale And Objectives: To establish a multimodal deep learning nomogram for predicting clinically significant prostate cancer in patients with gray-zone PSA levels.

Methods: This retrospective study enrolled 303 patients with pathological results between January 2018 and December 2022. Clinical variables and the PI-RADS v2.

Overloading And unpacKing (OAK) - droplet-based combinatorial indexing for ultra-high throughput single-cell multiomic profiling.

Multiomic profiling of single cells by sequencing is a powerful technique for investigating cellular diversity. Existing droplet-based microfluidic methods produce many cell-free droplets, underutilizing bead barcodes and reagents. Combinatorial indexing on microplates is more efficient for barcoding but labor-intensive.

Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.

PROTAC® (proteolysis-targeting chimera) molecules induce proximity between an E3 ligase and protein-of-interest (POI) to target the POI for ubiquitin-mediated degradation. Cooperative E3-PROTAC-POI complexes have potential to achieve neo-substrate selectivity beyond that established by POI binding to the ligand alone. Here, we extend the collection of ubiquitin ligases employable for cooperative ternary complex formation to include the C-degron E3 KLHDC2.

SARS-CoV-2 ferritin nanoparticle vaccines produce hyperimmune equine sera with broad sarbecovirus activity.

The rapid emergence of SARS-CoV-2 variants of concern (VoC) and the threat of future zoonotic sarbecovirus spillover emphasizes the need for broadly protective next-generation vaccines and therapeutics. We utilized SARS-CoV-2 spike ferritin nanoparticle (SpFN), and SARS-CoV-2 receptor binding domain ferritin nanoparticle (RFN) immunogens, in an equine model to elicit hyperimmune sera and evaluated its sarbecovirus neutralization and protection capacity. Immunized animals rapidly elicited sera with the potent neutralization of SARS-CoV-2 VoC, and SARS-CoV-1 pseudoviruses, and potent binding against receptor binding domains from sarbecovirus clades 1b, 1a, 2, 3, and 4.

Vaccine Potency and Structure of Yeast-Produced Polio Type 2 Stabilized Virus-like Particles.

Poliovirus (PV) is on the brink of eradication due to global vaccination programs utilizing live-attenuated oral and inactivated polio vaccines. Recombinant PV virus-like particles (VLPs) are emerging as a safe next-generation vaccine candidate for the impending polio-free era. In this study, we investigate the production, antigenicity, thermostability, immunogenicity, and structures of VLPs derived from PV serotype 2 (PV2) wildtype strain and thermally stabilized mutant (wtVLP and sVLP, respectively).

Idiopathic intracranial hypertension in Asians: a retrospective dual-center study.

Background: There have been limited data on idiopathic intracranial hypertension (IIH) in Asians and there remain uncertainties whether a cerebrospinal fluid (CSF) pressure of 250 mm CSF is an optimum diagnostic cutoff. The aims of the present study included (1) characterization of IIH patients in Taiwan, (2) comparisons among different diagnostic criteria for IIH, and (3) comparisons between patients with CSF pressures of > 250 and 200-250 mm CSF.

Methods: This retrospective study involved IIH patients based on the modified Dandy criteria from two tertiary medical centers in Taiwan.

Engineering Mn Vacancies to Enhance Ion Kinetics in Layered Manganese Silicate for High-Energy and Durable Intercalation Pseudocapacitance.

Transition metal silicates (TMSs) are potential electrodes for aqueous metal-ion intercalation pseudocapacitors owing to their superior theoretical capacity and high structural stability. However, the narrow interlayer spacing and intrinsic inert basal plane of TMSs lead to sluggish ions and charge transfer, causing an undesirable energy storage performance. Herein, rich Mn vacancies are introduced in layered manganous silicates (MS@FA) to expedite K diffusion, while enhancing charge storage capacity and prolonging lifespan.

Lithium metal based battery systems with ultra-high energy density beyond 500 W h kg.

As industries and consumption patterns evolve, new electrical appliances are increasingly playing critical roles in national production, defense, and cognitive exploration. However, the slow development of energy storage devices with ultra-high energy density (beyond 500 W h kg) has impeded the promotion and widespread application of the next generation of intelligent, multi-scenario electrical equipment. Among the numerous ultra-high specific energy battery systems, lithium metal batteries (LMBs) hold significant potential for applications in advanced and sophisticated fields.

Ni-doping optimized d-band center in bifunctional FeO modified by bamboo-like NCNTs as a cathode material for Zn-air batteries.

During the development of Zn-air batteries, designing an affordable, efficient and stable electrocatalyst for both oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) presents a great challenge. FeO exhibits ORR and OER activities, but when used as a cathode material in Zn-air batteries, its activity requires further improvement. To achieve this goal, Ni is doped into FeO hexagonal nanorods, derived from a metal-organic framework (MOF) precursor, and further modified by N-doped carbon nanotubes.

Optimisation of Mo doping to form NiCoMo ternary sulphides for high performance charge storage.

Multi-component synergy and the rational design of structures are effective methods for preparing electrode materials for high-performance energy storage devices. Transition metal-based hydroxides offer advantages such as a large specific surface area, large interlayer spacing, multiple redox states, and high theoretical capacity, making them commonly used as positive materials for supercapacitors. However, challenges like low conductivity and severe agglomeration limit their practical application.