Reduced miR-363-3p expression in non-small cell lung cancer is associated with gemcitabine resistance via targeting of CUL4A.

The article "Reduced miR-363-3p expression in non-small cell lung cancer is associated with gemcitabine resistance via targeting of CUL4A", W.-G. Bian, X.

Nanocomposites membranes from cellulose nanofibers, SiO and carboxymethyl cellulose with improved properties.

The binary nanocomposites blended by carboxymethyl cellulose (CMC) and SiO nanoparticles were constructed to prepare the films with superior thermal stability and flame retardant properties. The incorporation of cellulose nanofibers(CNFs) and SiO nanoparticles were followed to prepare ternary nanocomposite films exhibiting excellent mechanical properties. The mechanism and chemical reaction of the thermal decomposition for the CMC/SiO composite membrane were proposed, which showed that the mass residuals were NaCO, SiO and NaSiO, NaCO when the content of the SiO nanoparticles was lowered and higher than 9.

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.

Transient receptor potential canonical type 6 (TRPC6) is a nonselective receptor-operated cation channel that regulates reactive fibrosis and growth signaling. Increased TRPC6 activity from enhanced gene expression or gain-of-function mutations contribute to cardiac and/or renal disease. Despite evidence supporting a pathophysiological role, no orally bioavailable selective TRPC6 inhibitor has yet been developed and tested in vivo in disease models.