First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial.

Programmed cell death protein-1 (PD-1) inhibitors plus chemotherapy have been the standard of care in the first-line treatment of advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma; however, the survival benefits are modest in patients with low programmed death ligand 1 (PD-L1) expression. Here we investigated the efficacy and safety of cadonilimab (PD-1/cytotoxic T lymphocyte antigen-4 (CTLA-4) bispecific antibody) plus chemotherapy as first-line treatment in G/GEJ adenocarcinoma. The prespecified interim analysis is reported here.

Proximal protection devices for carotid artery stenting - A benchtop assessment of flow reversal performance.

Background And Purpose: Proximal protection devices, such as TransCarotid Artery Revascularization (TCAR, SilkRoad Medical, Sunnyvale), aim to yield better outcomes in carotid artery stenting (CAS) than distal protection devices by preventing plaque embolization to the brain. However, transfemoral catheters may not fully reverse flow from the external carotid artery (ECA) to the internal carotid artery (ICA). We assess a new balloon-sheath device, Femoral Flow Reversal Access for Carotid Artery Stenting (FFRACAS), for this purpose.

AI-boosted and motion-corrected, wireless near-infrared sensing system for continuously monitoring laryngeal muscles.

Neuromuscular diseases pose significant health and economic challenges, necessitating innovative monitoring technologies for personalizable treatment. Existing devices detect muscular motions either indirectly from mechanoacoustic signatures on skin surface or via ultrasound waves that demand specialized skin adhesion. Here, we report a wireless wearable system, Laryngeal Health Monitor (LaHMo), designed to be conformally placed on the neck for continuously measuring movements of underlying muscles.

(Gesneriaceae), a New Species From Southwestern Guangxi, China.

The genus is renowned for its remarkably diverse floral morphology, exhibiting a high level of disparity compared to most genera within Gesneriaceae. In this study, we present a detailed description and illustration of T. Ding & B.

, a new species of Salicaceae from limestone areas of Guangxi, China.

Z.C.Lu & W.

Folds from fold: Exploring topological isoforms of a single-domain protein.

Expanding the protein fold space beyond linear chains is of fundamental significance, yet remains largely unexplored. Herein, we report the creation of seven topological isoforms (i.e.

Construction and characterization of sesame meal-stabilized Pickering high internal phase emulsions and their application in cake production.

Pickering high internal phase emulsions (HIPEs) show promise for solid fat replacement and nutrient delivery, but the availability of safe and easily accessible food-borne particulate emulsifiers is a bottleneck limiting their practical application. In this study, the feasibility of using sesame meal as an emulsifier for the construction of sunflower oil-based Pickering HIPEs was evaluated. These HIPEs were then characterized in terms of their microstructural and mechanical properties, and utilized as a substitute for butter in cake production.

Synthesis and screening of a library of Lewis deoxyfluoro-analogues reveals differential recognition by glycan-binding partners.

Glycan-mediated interactions play a crucial role in biology and medicine, influencing signalling, immune responses, and disease pathogenesis. However, the use of glycans in biosensing and diagnostics is limited by cross-reactivity, as certain glycan motifs can be recognised by multiple biologically distinct protein receptors. To address this specificity challenge, we report the enzymatic synthesis of a 150-member library of site-specifically fluorinated Lewis analogues ('glycofluoroforms') using naturally occurring enzymes and fluorinated monosaccharides.

Opportunities to improve the diagnosis and treatment of primary hyperparathyroidism: retrospective cohort study.

Background: Although primary hyperparathyroidism (PHPT) is readily diagnosed biochemically and can be cured with low-risk surgery, it is often underrecognized and undertreated. Our objectives were to characterize, within our health system, how often patients with hypercalcemia were evaluated for PHPT and how often patients with PHPT underwent definitive treatment with parathyroidectomy.

Methods: Ambulatory patients aged 18 years or older seen at our health system between January 2018 and June 2023 with chronic hypercalcemia were identified from the medical record.

Erratum: Corrigendum: Liu W-B, Wang C-Y, Tang Y-N, Wang Y, Pei W-X, Yan C-C (2024) Six new species of Kieffer (Diptera, Chironomidae) from the Nearctic region. ZooKeys 1200: 275-302. doi: 10.3897/zookeys.1200.119225.

[This corrects the article DOI: 10.3897/zookeys.1200.

Single-Phase L1-Ordered High Entropy Thin Films with High Magnetic Anisotropy.

The vast high entropy alloy (HEA) composition space is promising for discovery of new material phases with unique properties. This study explores the potential to achieve rare-earth-free high magnetic anisotropy materials in single-phase HEA thin films. Thin films of FeCoNiMnCu sputtered on thermally oxidized Si/SiO substrates at room temperature are magnetically soft, with a coercivity on the order of 10 Oe.

Prognostic Value of a Multi-mRNA Signature for 1-Year All-Cause Death in Hospitalized Patients With Heart Failure With a Preserved Ejection Fraction.

Background: Heart failure with preserved ejection fraction is a major global public health problem, while effective risk stratification tools are still lacking. We sought to construct a multi-mRNA signature to predict 1-year all-cause death.

Methods: We selected 30 patients with heart failure with preserved ejection fraction who died during 1-year follow-up and 30 who survived in the discovery set.

Skin-inspired, sensory robots for electronic implants.

Drawing inspiration from cohesive integration of skeletal muscles and sensory skins in vertebrate animals, we present a design strategy of soft robots, primarily consisting of an electronic skin (e-skin) and an artificial muscle. These robots integrate multifunctional sensing and on-demand actuation into a biocompatible platform using an in-situ solution-based method. They feature biomimetic designs that enable adaptive motions and stress-free contact with tissues, supported by a battery-free wireless module for untethered operation.

Enhancing the Mechanical Properties and Water Permeability of Pervious Planting Concrete: A Study on Additives and Plant Growth.

Pervious planting concrete (PPC) is in line with the concept of ecological environmental protection. However, due to its own porous structure, it is difficult to obtain excellent mechanical properties and water permeability at the same time, which hinders its promotion and application. In this paper, natural gravel (NG), ordinary Portland cement (OPC), polyvinyl alcohol latex powder (PVAP) and polycarboxylate superplasticizer (PS) were used to prepare the PPC, and its mechanical properties and water permeability were studied.

Chloride Corrosion Process of Concrete with Different Water-Binder Ratios under Variable Temperature Drying-Wetting Cycles.

In this paper, four water-binder ratios (w/b) of 0.29, 0.33, 0.

Study on Flowability Regulation of Vacuum Gas-Atomized Fe-Cr-Ni-W-B Spherical Powder.

High-quality Fe-Cr-Ni-W-B spherical powder is crucial for the powder metallurgy preparation of high-strength and tough Fe-Cr-Ni-W-B alloys. In this study, the controlled preparation of high-quality Fe-Cr-Ni-W-B spherical powder was achieved using the vacuum gas atomization method. The effects and mechanisms of atomization gas pressure, the melt nozzle inner diameter, and heat treatment temperature on the microstructure and flowability of Fe-Cr-Ni-W-B spherical powder were systematically investigated.

 (Hydrangeaceae), a new species from Sichuan, China.

W.B.Ju & J.

Multiple interface coupling on natural tourmaline enables high-efficiency removal of antibiotic: Superior property and mechanism.

Reasonably designing highly active, environmentally friendly, and cost-effective catalysts for efficient elimination of pollutants from water is desirable but challenging. Herein, an efficient heterogeneous photo-Fenton catalyst tourmaline (TM)/tungsten oxide (WO) (named TW10) containing tungsten/boron/iron (W/B/Fe) synergistic active centers and 90% of cheap natural tourmaline (TM) mineral rich in Fe and B elements. The TW10 catalyst can quickly activate peroxymonosulfate (PMS) to generate massive active free radicals, which may induce the rapid and efficient degradation of tetracycline (TC).

TREX1 Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity.

Unlabelled: A substantial fraction of cancers evade immune detection by silencing Stimulator of Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation of this program via STING agonists, epigenetic, or DNA-damaging therapies can restore antitumor immunity in multiple preclinical models. Here we show that adaptive induction of three prime exonuclease 1 (TREX1) restrains STING-dependent nucleic acid sensing in cancer cells via its catalytic function in degrading cytosolic DNA.

Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules.

Homozygosity for the ε4 allele of APOE increases the odds of developing Alzheimer's by 12 to 15 times relative to the most common ε3;ε3 genotype, and its association with higher plaque loads comports with evidence that APOEε4 compromises autophagy. The ApoE4 protein specifically binds a cis element ("CLEAR") in the promoters of several autophagy genes to block their transcription. We used a multifaceted approach to identify a druggable site in ApoE4, and virtual screening of lead-like compounds identified small molecules that specifically bind to this site to impede ApoE4::DNA binding.

Enhancing geometric representations for molecules with equivariant vector-scalar interactive message passing.

Geometric deep learning has been revolutionizing the molecular modeling field. Despite the state-of-the-art neural network models are approaching ab initio accuracy for molecular property prediction, their applications, such as drug discovery and molecular dynamics (MD) simulation, have been hindered by insufficient utilization of geometric information and high computational costs. Here we propose an equivariant geometry-enhanced graph neural network called ViSNet, which elegantly extracts geometric features and efficiently models molecular structures with low computational costs.