Publications by authors named "W van Son"

Article Synopsis
  • The study aimed to compare the quality of consolidated bone in the anteromedial aspect of regenerated bone (AMRB) versus other areas (TORB) after using the induced membrane technique (IMT) for critical tibial shaft defects.
  • Results showed that AMRB experienced more negative changes in bone volume and density, and a lower rate of corticalization compared to TORB over a year, indicating poorer consolidation quality.
  • Factors identified that negatively affected consolidation in the AMRB include fracture-related infections, age, and defect length, which suggest that these variables should be considered in patient management and treatment outcomes.
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ErbB3 is markedly overexpressed in breast cancer cells and is associated with resistance and metastasis. Additionally, ErbB3 expression levels are positively correlated with low densities of tumor-infiltrating lymphocytes, a marker of poor prognosis. Consequently, ErbB3 is a promising therapeutic target for cancer immunotherapy.

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In elderly women, hormonal changes lead to elevated body fat content, which results in elevated levels of vascular inflammatory factors, thereby increasing the risk of cardiovascular diseases (CVDs) associated with endothelial dysfunction. Regular physical exercises tend to keep these in check and are protective to the body. Aerobic exercise has been reported to improve CVD in obese elderly women; in this regard, aquatic exercises have been demonstrated to be more efficient in energy metabolism than land-based exercise.

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Dendritic cells (DCs) are specialized immune cells that play a crucial role in presenting antigens and activating cytotoxic T lymphocytes to combat tumors. The immune checkpoint receptor programmed cell death-1 (PD-1) can bind to its ligand programmed cell death-ligand 1 (PD-L1), which is expressed on the surface of cancer cells. This interaction suppresses T-cell activation and promotes immune tolerance.

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