Publications by authors named "W van Aalderen"
Introduction: Wheezing is an important indicator of exacerbated respiratory symptoms in early childhood and must be monitored to regulate pharmacological therapy. However, parents' subjective perception of wheezing in their children is not always precise. We investigated the objective identification of children's wheezing by parents using a digital wheeze detector (WheezeScan, OMRON Healthcare Co.
View Article and Find Full Text PDFExhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study.
Am J Respir Crit Care Med
November 2024
Article Synopsis
- Early identification of poorly controlled asthma in children is crucial for improving treatment methods, and analyzing exhaled volatile organic compounds (VOCs) shows promise for this task.
- A study evaluated the effectiveness of gas chromatography-mass spectrometry to distinguish between controlled and uncontrolled pediatric asthma, using data from multiple research phases.
- Key findings revealed that specific VOCs, such as acetophenone and ethylbenzene, could differentiate asthma control levels, achieving strong accuracy in predicting outcomes based on the collected data from 196 children.
Introduction: Wheezing is common in preschool children and its clinical assessment often challenging for caretakers. This study aims to evaluate the impact of a novel digital wheeze detector (WheezeScan™) on disease control in a home care setting.
Methods: A multicentre randomised open-label controlled trial was conducted in Berlin, Istanbul and London.
Article Synopsis
- Children with preschool wheezing or school-age asthma have different microbial profiles in their airways, which can affect their condition and treatment outcomes.
- A study of oropharyngeal samples from 241 children identified four distinct clusters based on microbial composition, with significant differences in associated allergies and asthma severity.
- The findings suggest that understanding these microbial clusters could offer new insights into asthma management and lead to innovative treatment strategies.
Article Synopsis
- * The study analyzed oropharyngeal swab samples from children in a multicenter study, comparing microbiota between those with severe and mild/moderate asthma/wheeze using advanced gene sequencing techniques.
- * Although initial analyses showed no major differences in microbiota between severe and mild cases, a multivariable analysis revealed significant variations when considering factors like previous exacerbations and age-related microbial development.