[Biotransformation and pharmacokinetics of AWD 26-06, 8-chloro- 5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl]-11H-dibenzo[b,c] [1,4]diazepin-11-one hydrochloride, in the rat].

Following p.o. and i.

[Synthesis of 3-carbethoxyamino-5-dimethylamino-[1-14C]-acetyl- 10,11-dihydro-5h-dibenz[b,f]azepine hydrochloride (Bonnecor, AWD 19-166, GS 015)].

GS 015-14C was synthetized from [1-14C]-chloracetic acid and 3-carbethoxyamino-10,11-dihydro-5H-dibenz[b,f]azepine. The whole radioactivity yield passing all synthesis stages was 32% at a radiochemical purity of more than 98%.