Autosomal dominant "Opitz" GBBB syndrome due to a 22q11.2 deletion.

We report on a family with autosomal dominant paternally inherited "Opitz" GBBB syndrome and an additional case with findings which have been reported in that syndrome. In each case the propositus presented with a vascular ring. Since a vascular ring may be a sign of a 22q11.

Fever therapy: an educational intervention for parents.

Fever in children is a common problem, but one which often alarms parents. Parental misconceptions often lead them to unnecessarily aggressive and inappropriate management of fever in their children. A prospective controlled trial of an educational intervention to improve parental understanding and management of fever, involving the parents of 108 children, aged 6 months to 4 years, was performed in a private group practice.

A thyroxine-binding protein in human breast milk similar to serum thyroxine-binding globulin.

A thyroid hormone-binding substance (TBGw) similar to serum T4-binding globulin (TBG) has been identified in the whey fraction of human breast milk. TBGw coeluted with serum TBG, as determined by Bio-Gel P-100 chromatography, and has an isoelectric point of 4.2-4.

Intrafamilial transmission of Epstein-Barr virus infections.

Intrafamilial transmission of Epstein-Barr virus infections was studied in 35 familial. After infectious mononucleosis was diagnosed in an index child, all siblings were tested for antibodies to EBV. Susceptible children were retested in four to eight weeks.