1,3-disubstituted 2-thioxo-4,5-imidazolidinediones and 2,4,5-imidazolidinetriones and their anticonvulsant activity.

New unsymmetrically 1,3-disubstituted derivatives of 2-thioxo-4,5-imidazolidinedione (3, 5-7, 9-12) and 2,4,5-imidazolidinetrione (2, 8, 13-15) were synthesized by condensation of the respective thioureas and ureas with oxalyl chloride. They were screened for their central, mainly anticonvulsant activity and only compound 8 revealed antianxiety and antiepileptic properties.

Synthesis and pharmacological investigations of 3-(aminoalkylene)-1-aryl-2-thioxo-4,5-imidazolidinedione and 2,4,5-imidazolidinetrione derivatives.

New derivatives of 2-thioxo-4,5-imidazolidinedione (3-6, 10, 11) and 2,4,5-imidazolidinetrione (7, 12) were synthesized by N,N'-acylation of asymmetric thioureas and ureas by oxalyl chloride. The obtained compounds were screened for their central action, mainly anticonvulsant activity.

Synthesis and pharmacological investigation of compounds containing a 2-thioxopyrrolidine-4,5-dione moiety.

The synthesis of two Schiff bases of aryl methyl ketones and ethylenediamine 1c, 1d, symmetric adducts of aryl isothiocyanates with Schiff bases 2d-2m and 2-thioxopyrrolidine-4,5-dione derivatives 4d-4m obtained by condensation of oxalyl chloride with Schiff bases of aroylthioacetic acid anilides and ethylenediamine is described. Some of 13 investigated compounds 4a, 4b, 4d-4l, 5a, 5b of 2-thioxopyrrolidine-4,5-dione type showed sedative and analgesic action.

Synthesis and pharmacological activity of some 2,3-dihydrofuran-2,3-dione derivatives.

New 2,3-dihydrofuran-2,3-dione derivatives (1-11) were obtained by condensation of oxalyl chloride with Schiff bases of acetyl- or benzoylacetone and aromatic amines. These compounds showed only weak sedative action and weak analgesic effect.