Publications by authors named "W Z Gai"
Purpose: This study aimed to investigate the impact of herpesvirus detection by metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) on lower respiratory tract infections (LRTIs) patients' lung microbiome composition and prognosis.
Patients And Methods: We initially enrolled 234 hospitalized patients with LRTIs who underwent BALF mNGS between February 2022 and May 2023. The study analyzed the clinical manifestations and the pulmonary microbial composition between herpesvirus detection (HD) and non-herpesvirus detection (non-HD) group.
Q fever is a zoonotic disease caused by the Gram-negative bacterium , typically transmitted through exposure to infected animal secretions. As the clinical signs of Q-fever are largely non-specific in humans, a definitive diagnosis can often be overlooked, particularly when physicians fail to consider on the list of differentials. This case report describes Q-fever in a male patient who had previously undergone orthotopic liver transplantation.
View Article and Find Full Text PDFBackground: Alexithymia is characterized by an impaired ability in emotion awareness, expression, and regulation, associated with deficits in social and mental functioning. This study aims to develop a tool for addressing alexithymia and its psychological outcomes.
Method: In this paper, 102 subjects were recruited to investigate the relationship between alexithymia and psychological outcomes, along with the mediating role of emotion awareness, expression, and regulation.
Article Synopsis
- Antimicrobial resistance (AMR) poses a major risk to pediatric patients, especially in intensive care settings, highlighting the need for accurate identification of pathogens and resistance patterns to improve outcomes.
- A study analyzed data from 113 critically ill children in a pediatric intensive care unit, utilizing advanced sequencing techniques to identify pathogens and resistance genes, revealing a significant correlation between AMR and poorer clinical outcomes.
- The findings indicated that patients with AMR (AMRT+) had a higher prevalence of immunocompromised and underlying conditions, along with increased inflammatory markers, longer hospital stays, and a greater prevalence of certain resistant Gram-negative bacteria compared to those without AMR (AMRT-).
The contribution of the lung microbiota to pneumonia in children of varying severity remains poorly understood. This study utilized metagenomic next-generation sequencing (mNGS) technology to elucidate the characteristics of lung microbiota and their association with disease severity. This retrospective study analyzed bronchoalveolar lavage fluid (BALF) mNGS data of 92 children diagnosed with pneumonia between January 2021 and July 2022.
View Article and Find Full Text PDF