[Observation on destroyed architecture of splenic lymphoid follicles in mice infected with by immunohistochemistry].

To observe the destroyed architecture of splenic lymphoid follicles in mice infected with by immunohistochemistry. The mice infected with (20 cercariae/mouse) for 8 weeks were sacrificed, and the splenic samples were paraffin embedded and sliced. The sections were first stained by hematoxylin and eosin to observe the massive structure of splenic lymphoid follicles, and then B cells, follicular dendritic cells (FDC) and germinal center cells were labeled with anti-B220, anti-CD21 or anti-Ki67 antibodies respectively by immunohistochemistry to observe the distribution of the specific cells of lymphoid follicles.