Publications by authors named "W Y Yih"
Genetic risk factors for Mesoamerican nephropathy.
David J Friedman Dominick A Leone Juan José Amador Joseph Kupferman Lauren J Francey W Katherine Yih
Proc Natl Acad Sci U S A
December 2024
Article Synopsis
- * A study identified a strong link between Native American ancestry and an increased risk of MeN, while certain genetic variants were found to significantly reduce the odds of developing the disease.
- * Findings suggest that genetic differences in sensitivity to heat and dehydration contribute to the prevalence of kidney disease in these workers, highlighting both environmental and genetic factors.
Background: The JYNNEOS vaccine (two doses given 28 days apart) was recommended in the United States for people at high risk of exposure to monkeypox virus during the 2022 mpox outbreak. Our objective was to assess the safety of JYNNEOS using two complementary epidemiologic methods.
Methods: This observational cohort included patients of eight large integrated healthcare organizations who received JYNNEOS.
Article Synopsis
- The study aimed to investigate whether there is an increased occurrence of tinnitus (ringing in the ears) after COVID-19 vaccinations by analyzing data from U.S. vaccine safety surveillance systems.
- Using methods like Bayesian data mining and comparing visit rates, researchers looked at reports of tinnitus following vaccinations from 2020 to 2024.
- The results indicated no disproportionate reports of tinnitus linked to COVID-19 vaccines compared to influenza vaccines, particularly in younger populations, but there were slightly higher rates in individuals aged 65 and older for some COVID-19 vaccines.
Article Synopsis
- The study examines the safety of simultaneous vaccination (SV) with COVID-19 vaccines and other vaccines, analyzing data from the Vaccine Safety Datalink for those aged 5 and older.
- The findings show that SV with COVID-19 vaccines was infrequent, with only about 0.7% for the first dose and 0.3% for the second dose, primarily including vaccines like influenza and HPV.
- Overall, while most health outcomes following SV were rare and similar to those who didn't receive SV, there were some statistically significant increases in rates of specific conditions like appendicitis and Bell's palsy after certain doses.
Article Synopsis
- A study utilized tree-based data mining to identify potential adverse events following COVID-19 vaccinations from Pfizer-BioNTech, Moderna, and Janssen, focusing on a broad range of health outcomes rather than pre-specified conditions.
- The analysis involved monitoring patients for up to 70 days after vaccination, using a specific statistical method to determine clusters of incidents in emergency or inpatient settings, with a significance threshold set at p = 0.01.
- Notable findings included clusters of various common vaccine reactions and myocarditis/pericarditis post-Pfizer-BioNTech vaccination, while Moderna showed similar reactions without myocarditis clustering; Janssen vaccinees primarily reported unspecified reactions and some mobility issues likely influenced by site-specific practices.