The Role of Exerkines in the Treatment of Knee Osteoarthritis: From Mechanisms to Exercise Strategies.

With the increasing prevalence of knee osteoarthritis (KOA), the limitations of traditional treatments, such as their limited efficacy in halting disease progression and their potential side effects, are becoming more evident. This situation has prompted scientists to seek more effective strategies. In recent years, exercise therapy has gained prominence in KOA treatment due to its safety, efficacy, and cost-effectiveness, which are underpinned by the molecular actions of exerkines.

Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation.

Corneal substitutes with structural and compositional characteristics resembling those of natural corneas have attracted considerable attention. However, biomimicking the complex hierarchical organization of corneal stroma is challenging. In this study, humanized corneal stroma-like adhesive patches (HCSPs) are prepared through a multi-step process.

A Stable Open-Shelled Au26 Nanocluster with Remarkable Performance in Selective Oxidation of Benzyl Alcohol.

Open metal sites are crucial in catalysis. We have used a "loose coordination strategy" (LCS) to preorganize open metal sites in gold cluster catalysts. A gold nanocluster with composition of [Au26(3,4-Me2-Ph-form)9(iPr2-imy)3(Me2S)](BF4)2(iPr2-imy = 1,3-Diisopropylimidazolium tetrafluoroborate, 3,4-Me2-Ph-form = N,N'-Di(3,4-dimethyl-phenyl)formamidine) (Au26) has been obtained by one pot synthesis, i.

The Role of Autophagy in Copper-Induced Apoptosis and Developmental Neurotoxicity in SH-SY5Y Cells.

Copper (Cu) is a global environmental pollutant that poses a serious threat to humans and ecosystems. Copper induces developmental neurotoxicity, but the underlying molecular mechanisms are unknown. Neurons are nonrenewable, and they are unable to mitigate the excessive accumulation of pathological proteins and organelles in cells, which can be ameliorated by autophagic degradation.

Influence of starch on freeze-thaw stability of surimi gel observed via ice crystal distribution and gel properties.

Starch has been recognized as a vital ingredient in surimi products due to its ability to absorb water, which reduces the deterioration of gels and water loss during freezing and thawing. However, it is essential to ascertain the role of starch in the formation of ice crystals and the texture of surimi gels. The impact of freeze-thaw cycles on the morphology and distribution of ice crystals, as well as the textural characteristics of gelatinized and ungelatinized starch-surimi gels was investigated.