Associations of protein intake with the risk of fractures: A prospective cohort study of UK biobank participants.

Purpose: To evaluate the associations between protein intake and fractures risk in a large population-based cohort.

Methods: We conducted a prospective population-based study of UK Biobank. Participants aged 40-69 who completed the Oxford WebQ dietary questionnaire at least once were included.

12-month outcomes of pulsed-field ablation with a variable-diameter circular catheter for paroxysmal atrial fibrillation: Insights into conscious sedation and fluoroscopy use.

Background: Pulsed-field ablation (PFA) emerges as an innovative nonthermal energy modality for catheter ablation of atrial fibrillation (AF). This study aimed to assess the safety and effectiveness of a novel PFA system that uses a multichannel, circular ablation catheter with adjustable diameters in treating paroxysmal AF.

Methods: This clinical trial (PF-Beat-AF) was a prospective, multicenter, single-arm study.

Cross-Domain Diffusion with Progressive Alignment for Efficient Adaptive Retrieval.

Unsupervised efficient domain adaptive retrieval aims to transfer knowledge from a labeled source domain to an unlabeled target domain, while maintaining low storage cost and high retrieval efficiency. However, existing methods typically fail to address potential noise in the target domain, and directly align high-level features across domains, thus resulting in suboptimal retrieval performance. To address these challenges, we propose a novel Cross-Domain Diffusion with Progressive Alignment method (COUPLE).

High-resolution genome assembly and population genetic study of the endangered maple (Sapindaceae): implications for conservation strategies.

Diels (Sapindaceae), a highly threatened maple endemic to the dry-hot valleys of the Yalong River in western Sichuan, China, represents a valuable resource for horticulture and conservation. This study presents the first chromosomal-scale genome assembly of (~626 Mb, 2 = 26), constructed using PacBio HiFi and Hi-C sequencing technologies. Comparative genomic analyses revealed significant recent genomic changes through rapid amplification of transposable elements, particularly long terminal repeat retrotransposons, coinciding with the dramatic climate change during recent uplift of the Hengduan Mountains.

Evaluating Rituximab Failure Rates in Neuromyelitis Optica Spectrum Disorder: A Nationwide Real-World Study From South Korea.

Background And Purpose: Treatments for neuromyelitis optica spectrum disorder (NMOSD) such as eculizumab, ravulizumab, satralizumab, and inebilizumab have significantly advanced relapse prevention, but they remain expensive. Rituximab is an off-label yet popular alternative that offers a cost-effective solution, but its real-world efficacy needs better quantification for guiding the application of newer approved NMOSD treatments (ANTs). This study aimed to determine real-world rituximab failure rates to anticipate the demand for ANTs and aid in resource allocation.