CT-based radiomics predicts HRD score and HRD status in patients with ovarian cancer.

Introduction: This study predicted HRD score and status based on intra- and peritumoral radiomics in patients with ovarian cancer (OC) for better guiding the use of PARPi in clinical.

Methods: A total of 106 and 95 patients with OC were included between January 2022 and November 2023 for predicting HRD score and status, respectively. Radiomics features were extracted and quantitatively analyzed from intra- and peri-tumor regions in the CT image.

BRASSINAZOLE RESISTANT 1 delays photoperiodic flowering by repressing CONSTANS transcription.

Photoperiodic regulation of flowering time plays a critical role in plant reproductive success and crop yield. In Arabidopsis thaliana, the expression of the CONSTANS (CO) gene is closely regulated by day length and is modulated by both environmental and endogenous cues for precise control over flowering. Our findings reveal that the phytohormone brassinosteroid (BR) pathway represses flowering by inhibiting the expression of both CO and Flowering Locus T (FT).

L-cysteine modulates the Maillard reaction: Impacts on PhIP and pyrazine formation.

L-Cysteine (L-Cys) serves as both an inhibitor of the carcinogen 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and an enhancer of food flavor, supporting efforts to improve food safety and quality. Using a glucose/phenylalanine/creatinine model system, this study assessed the effects of varying L-Cys concentrations on PhIP inhibition and pyrazine flavor enhancement through UPLC-MS/MS and GC-MS analyses. The optimal PhIP reduction (82.

DNA methylation regulates somatic stress memory and mediates plasticity during acclimation to repeated sulfide stress in Urechis unicinctus.

Stress memory is an adaptive mechanism that enables organisms to develop resilience in response to environmental changes. Among them, somatic stress memory is an important means for organisms to cope with contemporary repeated stress, and is accompanied by transcription memory. Sulfide is a common environmental pollutant; however, some organisms have adapted to survive in sulfur-rich environments.

SNHG17 Reprograms Energy Metabolism of Breast Cancer by Activating Mitochondrial DNAs Transcription.

In most solid tumors, cellular energy metabolism is primarily dominated by aerobic glycolysis, which fulfills the high demand for biomacromolecules at the expense of reduced ATP production efficiency. Elucidation of the mechanisms by which rapidly proliferating malignant cells acquire sufficient energy in this state of inefficient ATP production from glycolysis could enable development of metabolism targeted therapeutic strategies. In this study, we observed a significant association between elevated expression levels of the long non-coding RNA (lncRNA) SNHG17 and unfavorable prognosis in breast cancer (BCa).