Publications by authors named "W Y Gonzalez"

Background: The optimal duration of external ventricular drain (EVD) in patients with aneurysmal subarachnoid hemorrhage (aSAH) is debatable. We sought to determine the association of EVD duration and output with outcomes, including cerebral infarct.

Methods: We performed a retrospective study of a prospectively collected cohort of consecutive patients with aSAH who were admitted to an academic center from 2016 to 2023.

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Anterior cruciate ligament reconstruction (ACLR), despite its effectiveness in restoring knee stability and function, can have associated morbidity. The most frequent complications are technical errors, which have been described during graft harvesting, tunnel placement or graft fixation. The most serious complications are neurovascular injuries, arthrofibrosis and infections.

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Oral squamous cell carcinoma (OSCC) is the most common manifestation of oral cancer. It has been proposed that periodontal pathogens contribute to OSCC progression, mainly by their virulence factors. However, the main periodontal pathogen and its mechanism to modulate OSCC cells remains not fully understood.

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Article Synopsis
  • Two-pore domain potassium (K2P) channels are crucial for regulating how cells respond to stimuli and function in the nervous system, and their selectivity filter structure is key to their ability to selectively allow potassium ions to pass.
  • The nematode has a large family of K2P channels with 47 genes, and this study focuses on the UNC-58 channel which is uniquely permeable to sodium ions due to a specific cysteine in its selectivity filter.
  • Through various experimental methods, the researchers found that UNC-58 causes depolarization in muscles and sensory neurons, leading to hypercontracted outcomes in gain-of-function mutants, highlighting the necessity of functional studies to understand how variations in selectivity filter sequences affect
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