Publications by authors named "W Y Back"
pH and Redox Dual-Responsive Nanoparticle with Enhanced Dendritic Cell Maturation for Cancer Therapy.
ACS Appl Mater Interfaces
November 2024
Type I interferons (IFNs) are essential for activating dendritic cells (DCs) and presenting tumor-associated antigens to T cells. IFNs are primarily produced from DCs among immune cells. A combination of chemotherapy and metalloimmunotherapy induces IFN production by activating the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway.
View Article and Find Full Text PDFGenitopatellar syndrome (GPS) and Say-Barber-Biesecker-Young-Simpson syndrome (SBBYSS) are rare genetic disorders linked to mutations in the Lysine Acetyltransferase 6B (KAT6B) gene, affecting histone acetylation regulation and developmental processes. We present a case of an African American infant with classic GPS features and a novel KAT6B gene mutation (c.4066del, p.
View Article and Find Full Text PDFArticle Synopsis
- Whipple's disease (WD) is a rare condition that affects multiple body systems, including the gut and joints, and can lead to serious complications like endocarditis, particularly in patients with underlying health issues like rheumatoid arthritis.
- A case study discusses a patient with coronary artery disease and rheumatoid arthritis who developed WD endocarditis potentially linked to the use of tocilizumab, an immunomodulator treatment.
- The report emphasizes the need for careful diagnosis and screening for WD in patients with tough-to-treat arthritis, suggesting noninvasive testing methods to identify the disease early.
Article Synopsis
- Cervical tuberculous lymphadenitis (CTL), also known as scrofula, arises from tuberculosis and is especially common in developing countries, but can also be found in developed nations.
- Diagnosing CTL is challenging due to its similarity to other conditions, leading clinicians to favor traditional RIPE therapy (rifampin, isoniazid, pyrazinamide, ethambutol) over aggressive surgical options due to potential severe complications.
- A rare side effect of isoniazid, a component of RIPE therapy, may be the development of acanthosis nigricans, as illustrated by a case of a young man from Nepal who experienced this skin condition likely as a result of the medication.
Article Synopsis
- Extracellular vesicles (EVs) are important for disease diagnosis and management, but isolating them from blood is challenging due to contamination from other proteins.
- A new, single-step method using positively charged beads effectively removes negatively charged impurities, resulting in purer EV samples.
- This efficient process takes about 20 minutes and could enhance EV use in liquid biopsies for early disease detection.