Publications by authors named "W Worodria"

: C-reactive protein (CRP)-based tuberculosis (TB) screening is recommended for people with HIV (PWH). However, its performance among people without HIV and in diverse settings is unknown. : In a multi-country study, we aimed to determine whether CRP meets the minimum accuracy targets (sensitivity ≥90%, specificity ≥70%) for an effective TB screening test.

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Article Synopsis
  • Effective diagnostic tests are crucial for detecting tuberculosis (TB) early in countries heavily affected by the disease, which led to a study screening adults with a cough in five countries.* -
  • The study involved several tests, including chest X-rays and multiple screening algorithms, assessing their accuracy against microbiological standards, revealing that CAD4TB was the most reliable test.* -
  • Combining different screening tests improved diagnostic accuracy, suggesting a sequential approach could better meet WHO standards for TB detection.*
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Cough is a common and commonly ignored symptom of lung disease. Cough is often perceived as difficult to quantify, frequently self-limiting, and non-specific. However, cough has a central role in the clinical detection of many lung diseases including tuberculosis (TB), which remains the leading infectious disease killer worldwide.

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Introduction: Chronic obstructive pulmonary disease (COPD) ranks among the top three global causes of death, with 90% of fatalities concentrated in low- and middle-income countries (LMICs). The projected rise in COPD burden, especially in LMICs, emphasizes the need to address the challenges for effective control and reversal of this trend. We aimed to provide an overview, and propose potential solutions to these challenges.

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OBJECTIVESPulmonary TB (PTB) increases the risk of chronic lung complications, which are associated with increased morbidity and mortality. We determined the prevalence and predictors of post-TB lung disease and persistent symptoms in a resource-limited setting.METHODSAdults who completed PTB treatment underwent spirometry and completed the St.

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