Publications by authors named "W Wohlleben"
Article Synopsis
- The implementation of Safe and Sustainable by Design (SSbD) and grouping approaches requires effective and cost-efficient assays for early hazard screening, particularly for nanomaterials (NMs).
- Oxidative potential (OP), indicating a substance’s ability to produce harmful reactive oxygen species (ROS), is a key factor in assessing potential oxidative damage, often measured using the ferric reducing ability of serum (FRAS) assay.
- A modified 96-well format of the FRAS assay enhances user-friendliness and throughput, allowing for simultaneous screening of multiple NMs, although it shows slightly lower precision than the original cuvette-based method while still maintaining acceptable variability in results.
Article Synopsis
- * New methods were employed to assess the hazards and benefits of these perovskites, revealing that their composition affects stability under lung conditions, leading to oxidative damage and the release of metals.
- * The study identified a version of perovskite with lower nickel and added palladium as the most balanced option for safe and sustainable design, though it did not enhance traditional catalytic performance, suggesting potential need for redesign in the industry.
Glycopeptide antibiotics (GPAs) are peptide natural products used as last resort treatments for antibiotic resistant bacterial infections. They are produced by the sequential activities of a linear nonribosomal peptide synthetase (NRPS), which assembles the heptapeptide core of GPAs, and cytochrome P450 (Oxy) enzymes, which perform a cascade of cyclisation reactions. The GPAs contain proteinogenic and nonproteinogenic amino acids, including phenylglycine residues such as 4-hydroxyphenylglycine (Hpg).
View Article and Find Full Text PDFThe natural soil environment of is characterized by variations in the availability of nitrogen, carbon, phosphate and sulfur, leading to complex primary and secondary metabolisms. Their remarkable ability to adapt to fluctuating nutrient conditions is possible through the utilization of a large amount of substrates by diverse intracellular and extracellular enzymes. Thus, fulfill an important ecological role in soil environments, metabolizing the remains of other organisms.
View Article and Find Full Text PDFThis manuscript discusses the challenges of applying New Approach Methodologies (NAMs) for safe by design and regulatory risk assessment of advanced nanomaterials (AdNMs). The authors propose a framework for Next Generation Risk Assessment of AdNMs involving NAMs that is aligned to the conventional risk assessment paradigm. This framework is exposure-driven, endpoint-specific, makes best use of pre-existing information, and can be implemented in tiers of increasing specificity and complexity of the adopted NAMs.
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