Publications by authors named "W Wisitrasameewong"
The Potential Effect of Periodontal Disease on the Development of Metabolic Syndrome: A 10-Year Observational Study in a Thai Adult Cohort.
J Clin Periodontol
September 2024
Aim: As data are sparse on the long-term association between periodontal diseases and development of metabolic syndrome (MetS), we investigated their relationship in a Thai cohort over a 10-year observational period.
Methods: Medical records and data on periodontal assessments of 2161 employees of the Electricity Generating Authority of Thailand collected at two time points, 2003 and 2013, were used. Experienced periodontists used standard national and international criteria to define periodontitis and MetS.
Article Synopsis
- This study investigates the impact of different silk ligature sizes on alveolar bone loss in a rat model of ligature-induced periodontitis, which is useful for testing new dental treatments.
- The ligatures used were 3-0, 4-0, and 5-0, and the results indicated that the 3-0 and 4-0 sizes led to significantly greater bone loss compared to the 5-0 ligature, with the 3-0 ligature having the highest retention.
- After removing the ligatures, bone healing was assessed, revealing no significant changes in bone levels two weeks post-removal, despite elevated levels of inflammatory markers IL-1β and TNF-α during the study.
Article Synopsis
- Bone remodeling involves communication between osteoclasts and osteoblasts, regulated by factors like Semaphorin 4D (Sema4D), which inhibits the formation of osteoblasts.
- Sema4D is produced in two forms (membrane-bound and soluble), and its shedding from osteoclasts is primarily mediated by TACE, with inhibition of TACE leading to reduced levels of sSema4D.
- Experiments show that when TACE function is blocked, the suppression of osteoblast activity is lifted, indicating a potential therapeutic pathway to enhance bone formation by targeting TACE and Sema4D interactions.
Studies of human microbiomes using new sequencing techniques have increasingly demonstrated that their ecologies are partly determined by the lifestyle and habits of individuals. As such, significant forensic information could be obtained from high throughput sequencing of the human microbiome. This approach, combined with multiple analytical techniques demonstrates that bacterial DNA can be used to uniquely identify an individual and to provide information about their life and behavioral patterns.
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