Corticosteroid injection up to 8 weeks prior to ACL reconstruction doubles the incidence of post-operative infection.

Purpose: This study was performed to determine if at least one corticosteroid injection (CSI) within 8-weeks prior to Anterior Cruciate Ligament Reconstruction (ACL-R) increases the incidence of postoperative infection.

Methods: A large globally federated research database (TriNetX) containing over 200 million patient records was retrospectively queried for patients undergoing ACL-R between October 1st, 2010, and January 1st, 2024 using diagnosis and procedure codes. A cohort of patients receiving CSI up to 8-weeks prior to ACL-R were compared to a cohort of patients who did not receive a CSI prior to ACL-R.

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements.

MYC-driven (MYC+) cancers are aggressive and often fatal. MYC dysregulation is a key event in these cancers, but overexpression of MYC alone is not always enough to cause cancer. (), a long non-coding RNA (lncRNA) adjacent to MYC on chromosome 8 is a rearrangement hotspot in many MYC+ cancers.

A randomized comparative effectiveness trial to evaluate two programs for promotion of physical activity after spinal cord injury in manual wheelchair users.

Objective: The goal of this study was to determine the effectiveness of a novel whole of day activity accumulation (WODAA) physical exercise program. WODAA physical activity and physiological outcomes were compared to outcomes from individuals using a traditional planned arm crank exercise (PACE) program. Both programs included progressive exercise instruction and goal setting over a 4-month period, and utilization of a wrist-worn activity monitor (Fitbit Blaze/Versa, Fitbit Inc.

Cellular morphometric biomarkers and large language model predict prognosis and treatment response in neuroblastoma patients: A retrospective and double-blind prospective single arm clinical study.

Background: The heterogeneity of Neuroblastoma (NB) leads to variation in response to treatment and outcomes. The aim of the current study is to discover AI-empowered cellular morphometric biomarkers (CMBs), to establish the corresponding CMB risk score (CMBRS), CMB risk group (CMBRG), large language model driven CMB risk score (CMB-LLM-RS), and large language model driven CMB risk group (CMB-LLM-RG), and to investigate and validate their prognostic and predictive power in NB.

Methods: In this study, the retrospective cohort enrolled 84 primary NBs between 1/2020 and 12/2021, followed up through 11/22/2024; the prospective cohort enrolled 67 primary NBs between 1/2022 and 7/2023, followed up through 11/22/2024.

Frequency of Tommy John Surgery in NCAA Division I College Pitchers Versus Weather Conditions.

Background: Ulnar collateral ligament reconstruction (UCLR) is a common elbow procedure in baseball pitchers. Previous studies of Major League Baseball pitchers identified the weather as a potential risk factor, as warmer climates enable more annual playing time and increase overuse injury risks.

Purpose: To determine whether weather conditions play a role in UCLR rates and timing for National Collegiate Athletic Association (NCAA) Division I (D1) collegiate pitchers in the United States.