Unraveling the role of water in mechanism changes for economically viable catalytic plastic upcycling.

The surge in global plastic production, reaching 400.3 million tons in 2022, has exacerbated environmental pollution, with only 11% of plastic being recycled. Catalytic recycling, particularly through hydrogenolysis and hydrocracking, offers a promising avenue for upcycling polyolefin plastic, comprising 55% of global plastic waste.

Ultra-fast genetically encoded sensor for precise real-time monitoring of physiological and pathophysiological peroxide dynamics.

Hydrogen Peroxide (HO) is a central oxidant in redox biology due to its pleiotropic role in physiology and pathology. However, real-time monitoring of HO in living cells and tissues remains a challenge. We address this gap with the development of an optogenetic hydRogen perOxide Sensor (oROS), leveraging the bacterial peroxide binding domain OxyR.

Python-Based Algorithm for Estimating the Parameters of Physical Property Models for Substances Not Available in Database.

An in-house Python-based algorithm was developed using simplified molecular-input line-entry specification (SMILES) strings and a dipole moment for estimating the normal boiling point, critical properties, standard enthalpy, vapor pressure, liquid molar volume, enthalpy of vaporization, heat capacity, viscosity, thermal conductivity, and surface tension of molecules. Normal boiling point, critical properties, and standard enthalpy were estimated by using the Joback group contribution method. Vapor pressure, liquid molar volume, enthalpy of vaporization, heat capacity, and surface tension were estimated by using the Riedel model, Gunn-Yamada model, Clausius-Clapeyron equation, Joback group contribution method, and Brock-Bird model, respectively.

Structure-guided engineering of a fast genetically encoded sensor for real-time HO monitoring.

Hydrogen Peroxide (HO) is a central oxidant in redox biology due to its pleiotropic role in physiology and pathology. However, real-time monitoring of HO in living cells and tissues remains a challenge. We address this gap with the development of an optogenetic hydRogen perOxide Sensor (oROS), leveraging the bacterial peroxide binding domain OxyR.