Publications by authors named "W W Watkins"
Article Synopsis
- - This study investigates how heritability affects hearing acuity across different frequencies by analyzing 34 family pedigrees from the Utah CEPH, using genomic sequencing and audiometric tests.
- - Results show that heritability decreases as frequency increases, with estimates going from 51% at 250Hz to 30% at 8000Hz, indicating stronger genetic influence at lower frequencies.
- - The genetic correlation between hearing acuity at similar frequencies is high (e.g., 0.80 between 250Hz and 500Hz), while correlations drop significantly between distant frequencies (0.21 between 250Hz and 8000Hz), highlighting the nuanced genetic factors affecting hearing abilities.
Article Synopsis
- Researchers discovered a strong and selective antagonist for the lysophosphatidic acid receptor 1 (LPAR1), which has antifibrotic properties, initially validated through a specific assay involving MRTF-A.* -
- Structural modifications improved the compound's stability and pharmacokinetics, leading to a promising candidate for oral dosing that effectively blocked LPA-induced histamine release and showed efficacy against lung fibrosis in preclinical tests.* -
- Despite its potential, the development of the LPAR1 antagonist was discontinued due to observed CNS toxicity in dog models, raising safety concerns for clinical use in idiopathic pulmonary fibrosis (IPF).*
We describe a new type of spectropolarimeter in which light is separated to simultaneously measure six spectra carrying polarimetric information on a 2D CMOS camera. The polarization separation along one of the camera axes was obtained using a novel prism, and the spectral dispersion along the other camera axis was obtained using an imaging spectrometer. An ideal version of the six-fold separating prism is first described, in which polarimetric separation is performed along the canonical polarization states used to define the Stokes vector, and it can be explained without any math.
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- bRT before CAR T-cell therapy for LBCL is gaining traction, but its impact on treatment outcomes is unclear.
- A study analyzed 23 LBCL patients who underwent bRT followed by CAR T-cell therapy, focusing on various PET scan metrics to measure tumor response.
- Results revealed that significant decreases in SUV and MTV during bRT were linked to better progression-free survival, freedom from distant progression, and local control.
- The findings suggest that greater cytoreduction via bRT may enhance the effectiveness of subsequent CAR T-cell therapy in treating large B-cell lymphoma.
Prematurity-associated lung disease (PLD) is a long-term consequence of preterm-birth. Since the underlying mechanisms of PLD remain poorly characterised, we compared the urinary metabolome between recently described spirometry phenotypes of PLD. Preterm- and term-born children aged 7-12 years, from the Respiratory Health Outcomes in Neonates (RHiNO) cohort, underwent spirometry and urine collection.
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